Natural Products and Their Therapeutic Effect on Autism Spectrum Disorder

Satarupa Deb, Banashree Chetia Phukan, Ankumoni Dutta, Rajib Paul, Pallab Bhattacharya, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Chidambaram Saravana Babu, Musthafa Mohamed Essa, Anupom Borah*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autism is a complex neurodevelopmental disorder that is evident in early childhood and can persist throughout the entire life. The disease is basically characterized by hurdles in social interaction where the individuals demonstrate repetitive and stereotyped interests or patterns of behavior. A wide number of neuroanatomical studies with autistic patients revealed alterations in brain development which lead to diverse cellular and anatomical processes including atypical neurogenesis, neuronal migration, maturation, differentiation, and degeneration. Special education programs, speech and language therapy, have been employed for the amelioration of behavioral deficits in autism. Although commonly prescribed antidepressants, antipsychotics, anticonvulsants, and stimulants have revealed satisfactory responses in autistic individuals, adverse side effects and increased risk of several other complications including obesity, dyslipidemia, diabetes mellitus, thyroid disorders, etc. have compelled the researchers to turn their attention toward herbal remedies. Alternative approaches with natural compounds are on continuous clinical trial to confirm their efficacy and to understand their potential in autism treatment. This chapter aims to cover the major plant-based natural products which hold promising outcomes in the field of reliable therapeutic interventions for autism.

Original languageEnglish
Title of host publicationAdvances in Neurobiology
PublisherSpringer
Pages601-614
Number of pages14
DOIs
Publication statusPublished - Jan 1 2020

Publication series

NameAdvances in Neurobiology
Volume24
ISSN (Print)2190-5215
ISSN (Electronic)2190-5223

Keywords

  • Antidepressants
  • Antipsychotics
  • ASD, autism
  • Herbal remedies
  • Neurodevelopmental disorder
  • Neurotherapeutics, natural products, nutrition therapy, neuronal migration

ASJC Scopus subject areas

  • Biochemistry
  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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