Abstract
Aim: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2. Methods: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. Results: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. Conclusion: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.
| Original language | English |
|---|---|
| Pages (from-to) | 2697-2702 |
| Number of pages | 6 |
| Journal | World Journal of Gastroenterology |
| Volume | 13 |
| Issue number | 19 |
| Publication status | Published - May 21 2007 |
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Keywords
- Arab
- Gastric cancer
- H pylori
- NAT2
- Omani
- Polymorphism
ASJC Scopus subject areas
- Gastroenterology
Cite this
NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations. / Al-Moundhri, Mansour; Al-Kindi, Mohamed; Al-Nabhani, Maryam; Al-Bahrani, Bassim; Burney, Ikram A.; Al-Madhani, Ali; Ganguly, Shyam S.; Tanira, Misbah.
In: World Journal of Gastroenterology, Vol. 13, No. 19, 21.05.2007, p. 2697-2702.Research output: Contribution to journal › Article
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TY - JOUR
T1 - NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations
AU - Al-Moundhri, Mansour
AU - Al-Kindi, Mohamed
AU - Al-Nabhani, Maryam
AU - Al-Bahrani, Bassim
AU - Burney, Ikram A.
AU - Al-Madhani, Ali
AU - Ganguly, Shyam S.
AU - Tanira, Misbah
PY - 2007/5/21
Y1 - 2007/5/21
N2 - Aim: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2. Methods: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. Results: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. Conclusion: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.
AB - Aim: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2. Methods: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. Results: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. Conclusion: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.
KW - Arab
KW - Gastric cancer
KW - H pylori
KW - NAT2
KW - Omani
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=34250753726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250753726&partnerID=8YFLogxK
M3 - Article
VL - 13
SP - 2697
EP - 2702
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 19
ER -