NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations

Mansour Al-Moundhri, Mohamed Al-Kindi, Maryam Al-Nabhani, Bassim Al-Bahrani, Ikram A. Burney, Ali Al-Madhani, Shyam S. Ganguly, Misbah Tanira

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aim: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2. Methods: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. Results: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. Conclusion: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.

Original languageEnglish
Pages (from-to)2697-2702
Number of pages6
JournalWorld Journal of Gastroenterology
Volume13
Issue number19
Publication statusPublished - May 21 2007

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Acetyltransferases
Stomach Neoplasms
Phenotype
Genotype
Pylorus
DNA Sequence Analysis
Multivariate Analysis
Smoking

Keywords

  • Arab
  • Gastric cancer
  • H pylori
  • NAT2
  • Omani
  • Polymorphism

ASJC Scopus subject areas

  • Gastroenterology

Cite this

NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations. / Al-Moundhri, Mansour; Al-Kindi, Mohamed; Al-Nabhani, Maryam; Al-Bahrani, Bassim; Burney, Ikram A.; Al-Madhani, Ali; Ganguly, Shyam S.; Tanira, Misbah.

In: World Journal of Gastroenterology, Vol. 13, No. 19, 21.05.2007, p. 2697-2702.

Research output: Contribution to journalArticle

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AU - Al-Moundhri, Mansour

AU - Al-Kindi, Mohamed

AU - Al-Nabhani, Maryam

AU - Al-Bahrani, Bassim

AU - Burney, Ikram A.

AU - Al-Madhani, Ali

AU - Ganguly, Shyam S.

AU - Tanira, Misbah

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N2 - Aim: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2. Methods: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. Results: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. Conclusion: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.

AB - Aim: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2. Methods: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. Results: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. Conclusion: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.

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