TY - JOUR
T1 - Myeloid-derived suppressor cells
T2 - Their role in the pathophysiology of hematologic malignancies and potential as therapeutic targets
AU - Younos, Ibrahim H.
AU - Abe, Fuminori
AU - Talmadge, James E.
N1 - Publisher Copyright:
© 2015 © 2015 Informa UK, Ltd.
PY - 2015/8/3
Y1 - 2015/8/3
N2 - Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells at various stages of differentiation/maturation that have a role in cancer induction and progression. They function as vasculogenic and immunosuppressive cells, utilizing multiple mechanisms to block both innate and adaptive anti-tumor immunity. Recently, their mechanism of action and clinical importance have been defined, and the cross-talk between myeloid cells and cancer cells has been shown to contribute to tumor induction, progression, metastasis and tolerance. In this review, we focus on the role of MDSCs in hematologic malignancies and the therapeutic approaches targeting MDSCs that are currently in clinical studies.
AB - Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells at various stages of differentiation/maturation that have a role in cancer induction and progression. They function as vasculogenic and immunosuppressive cells, utilizing multiple mechanisms to block both innate and adaptive anti-tumor immunity. Recently, their mechanism of action and clinical importance have been defined, and the cross-talk between myeloid cells and cancer cells has been shown to contribute to tumor induction, progression, metastasis and tolerance. In this review, we focus on the role of MDSCs in hematologic malignancies and the therapeutic approaches targeting MDSCs that are currently in clinical studies.
KW - Myeloid-derived suppressor cells
KW - hematologic malignancies
KW - leukemia
KW - lymphoma
KW - multiple myeloma
UR - http://www.scopus.com/inward/record.url?scp=84941897868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941897868&partnerID=8YFLogxK
U2 - 10.3109/10428194.2014.987141
DO - 10.3109/10428194.2014.987141
M3 - Review article
C2 - 25407654
AN - SCOPUS:84941897868
SN - 1042-8194
VL - 56
SP - 2251
EP - 2263
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 8
ER -