Proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor. Mutations in the PCSK9 gene have previously been found to segregate with autosomal dominant familial hypercholesterolemia (ADFH). In this study, DNA sequencing of the 12 exons of the PCSK9 gene has been performed for two patients with a clinical diagnosis of familial hypercholesterolemia where mutation in the LDL-receptor gene hasn't been excluded. One missense mutation was detected in the exon 9 PCSK9 gene in the two ADFH patients. Te patients were found to be heterozygote for Ile474Val (SNP rs562556). Using an array of in silico tools, we have investigated the efect of the above mutation on diferent structural levels of the PCSK9 protein. Although, the mutation has already been reported in the literature for other populations, to the best of our knowledge this is the frst report of a mutation in the PCSK9 gene from the Arab population, including the Omani population.
- Autosomal dominant hypercholesterolemia
- PCSK9 protien
ASJC Scopus subject areas