@inbook{db631c4ca8b04d1a9caeeeda6a6718df,
title = "Multiplex Testing of the Effect of Statins on Disease Severity Risk in COVID-19 Cases",
abstract = "Statins have pleiotropic effects on inflammatory responses in addition to their lipid-lowering action, which contributes to their favorable effect on cardiovascular disorders. Statins affect adhesion, migration, antigen presentation, and cytokine generation of immune cells. Pre-clinical and clinical studies suggest that statin intervention targeted early in the infection might help COVID-19 patients to reduce the effects of acute respiratory distress syndrome (ARDS), the cytokine storm, and vascular collapse by modulating harmful pathogenic mechanisms. This chapter presents a protocol for measuring blood-based biomarkers predictive of these responses in COVID-19 patients using two specific multiplex immunoassays that target proteins that differ widely in concentration.",
keywords = "C-reactive protein, COVID-19, IL-6, IL-8, Multiplex immunoassay, SARS-CoV-2, Simvastatin, Statins, TNF-α, Von Willebrand factor",
author = "Fatemeh Zahedipour and Guest, {Paul C.} and Muhammed Majeed and Khalid Al-Rasadi and Tannaz Jamialahmadi and Amirhossein Sahebkar",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2022",
doi = "10.1007/978-1-0716-2395-4_20",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "273--284",
booktitle = "Methods in Molecular Biology",
}