Multiplex Testing of the Effect of Statins on Disease Severity Risk in COVID-19 Cases

Fatemeh Zahedipour, Paul C. Guest, Muhammed Majeed, Khalid Al-Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Statins have pleiotropic effects on inflammatory responses in addition to their lipid-lowering action, which contributes to their favorable effect on cardiovascular disorders. Statins affect adhesion, migration, antigen presentation, and cytokine generation of immune cells. Pre-clinical and clinical studies suggest that statin intervention targeted early in the infection might help COVID-19 patients to reduce the effects of acute respiratory distress syndrome (ARDS), the cytokine storm, and vascular collapse by modulating harmful pathogenic mechanisms. This chapter presents a protocol for measuring blood-based biomarkers predictive of these responses in COVID-19 patients using two specific multiplex immunoassays that target proteins that differ widely in concentration.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages273-284
Number of pages12
DOIs
Publication statusPublished - 2022

Publication series

NameMethods in Molecular Biology
Volume2511
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • C-reactive protein
  • COVID-19
  • IL-6
  • IL-8
  • Multiplex immunoassay
  • SARS-CoV-2
  • Simvastatin
  • Statins
  • TNF-α
  • Von Willebrand factor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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