Multicenter validation of spin-density projection-assisted R2-MRI for the noninvasive measurement of liver iron concentration

Tim G. St. Pierre, Amal El-Beshlawy, Mohsen Elalfy, Abdullah Al Jefri, Kusai Al Zir, Shahina Daar, Dany Habr, Ulrike Kriemler-Krahn, Ali Taher

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64 Citations (Scopus)

Abstract

Purpose: Magnetic resonance imaging (MRI)-based techniques for assessing liver iron concentration (LIC) have been limited by single scanner calibration against biopsy. Here, the calibration of spin-density projection-assisted (SDPA) R2-MRI (FerriScan®) in iron-overloaded β-thalassemia patients treated with the iron chelator, deferasirox, for 12 months is validated. Methods: SDPA R2-MRI measurements and percutaneous needle liver biopsy samples were obtained from a subgroup of patients (n=233) from the ESCALATOR trial. Five different makes and models of scanner were used in the study. Results LIC, derived from mean of MRI- and biopsy-derived values, ranged from 0.7 to 50.1 mg Fe/g dry weight. Mean fractional differences between SDPA R2-MRI- and biopsy-measured LIC were not significantly different from zero. They were also not significantly different from zero when categorized for each of the Ishak stages of fibrosis and grades of necroinflammation, for subjects aged 3 to

Original languageEnglish
Pages (from-to)2215-2223
Number of pages9
JournalMagnetic Resonance in Medicine
Volume71
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • biopsy
  • deferasirox
  • ESCALATOR
  • iron overload
  • β-thalassemia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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    St. Pierre, T. G., El-Beshlawy, A., Elalfy, M., Al Jefri, A., Al Zir, K., Daar, S., Habr, D., Kriemler-Krahn, U., & Taher, A. (2014). Multicenter validation of spin-density projection-assisted R2-MRI for the noninvasive measurement of liver iron concentration. Magnetic Resonance in Medicine, 71(6), 2215-2223. https://doi.org/10.1002/mrm.24854