Multi-drug resistance of Escherichia coli from the urinary tract

Akbar Mohammed Rafay, Herbert N. Nsanze

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: Resistance to antimicrobials of different structural classes has arisen in a multitude of bacterial species. This may complicate the therapeutic management of infections, including those of the urinary tract. The aim of this study is to show that antibiotic resistance surveillance is essential. Methods: A total of 11,126 urine samples were received at Sultan Qaboos University Hospital (SQUH), Muscat, Sultanate of Oman, for one year period (2001), they were cultured for bacterial pathogen and sensitivity was performed for all significant isolates. Results: Eight hundred and eighty-four samples were culture positive with Escherichia coli (E.coli) (N=445) as the most common enterobacteriaceae, followed by Klebsiella pneumoniae (N=161), unidentified Coliforms (N=56) and Klebsiella species (N=33). High rate of resistance to β-Lactams was seen for all Enterobacteriaceae, maximum resistance was against ampicillin (78.6%) followed by co-amoxiclav (44.6%), but cefuroxime demonstrated the least resistance. Resistance to quinolone ranged from 4.7%-21.2% for all Enterobacteriaceae, cotrimoxazole resistance for all Enterobacteriaceae was 32.1%. Multi-drug resistance of E.coli was analyzed, 11.2% (50 of 445) were resistant to 3 or more antimicrobials and considered multidrug resistant. Among the multidrug-resistant isolates, 88% were resistant co-amoxiclav or cotrimoxazole, gentamicin 62%, ciprofloxacin 66%, and nitrofurantoin 32%. The predominant phenotype among multidrug-resistant isolates (26%; 13 of 50) included resistance to co-amoxiclav, gentamicin, and cotrimoxazole. This was the most common phenotype followed by 20%, of co-amoxiclav, cotrimoxazole and ciprofloxacin. Conclusion: In view of the current prevalence of multi-drug resistance among urinary tract isolates of E.coli at the SQUH (11.2%), continued surveillance will be beneficial.

Original languageEnglish
Pages (from-to)261-264
Number of pages4
JournalSaudi Medical Journal
Volume24
Issue number3
Publication statusPublished - Mar 1 2003

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Amoxicillin-Potassium Clavulanate Combination
Sulfamethoxazole Drug Combination Trimethoprim
Multiple Drug Resistance
Enterobacteriaceae
Urinary Tract
Escherichia coli
Ciprofloxacin
Gentamicins
Oman
Phenotype
Nitrofurantoin
Lactams
Cefuroxime
Klebsiella
Quinolones
Klebsiella pneumoniae
Ampicillin
Microbial Drug Resistance
Urine
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Multi-drug resistance of Escherichia coli from the urinary tract. / Rafay, Akbar Mohammed; Nsanze, Herbert N.

In: Saudi Medical Journal, Vol. 24, No. 3, 01.03.2003, p. 261-264.

Research output: Contribution to journalArticle

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title = "Multi-drug resistance of Escherichia coli from the urinary tract",
abstract = "Objectives: Resistance to antimicrobials of different structural classes has arisen in a multitude of bacterial species. This may complicate the therapeutic management of infections, including those of the urinary tract. The aim of this study is to show that antibiotic resistance surveillance is essential. Methods: A total of 11,126 urine samples were received at Sultan Qaboos University Hospital (SQUH), Muscat, Sultanate of Oman, for one year period (2001), they were cultured for bacterial pathogen and sensitivity was performed for all significant isolates. Results: Eight hundred and eighty-four samples were culture positive with Escherichia coli (E.coli) (N=445) as the most common enterobacteriaceae, followed by Klebsiella pneumoniae (N=161), unidentified Coliforms (N=56) and Klebsiella species (N=33). High rate of resistance to β-Lactams was seen for all Enterobacteriaceae, maximum resistance was against ampicillin (78.6{\%}) followed by co-amoxiclav (44.6{\%}), but cefuroxime demonstrated the least resistance. Resistance to quinolone ranged from 4.7{\%}-21.2{\%} for all Enterobacteriaceae, cotrimoxazole resistance for all Enterobacteriaceae was 32.1{\%}. Multi-drug resistance of E.coli was analyzed, 11.2{\%} (50 of 445) were resistant to 3 or more antimicrobials and considered multidrug resistant. Among the multidrug-resistant isolates, 88{\%} were resistant co-amoxiclav or cotrimoxazole, gentamicin 62{\%}, ciprofloxacin 66{\%}, and nitrofurantoin 32{\%}. The predominant phenotype among multidrug-resistant isolates (26{\%}; 13 of 50) included resistance to co-amoxiclav, gentamicin, and cotrimoxazole. This was the most common phenotype followed by 20{\%}, of co-amoxiclav, cotrimoxazole and ciprofloxacin. Conclusion: In view of the current prevalence of multi-drug resistance among urinary tract isolates of E.coli at the SQUH (11.2{\%}), continued surveillance will be beneficial.",
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AB - Objectives: Resistance to antimicrobials of different structural classes has arisen in a multitude of bacterial species. This may complicate the therapeutic management of infections, including those of the urinary tract. The aim of this study is to show that antibiotic resistance surveillance is essential. Methods: A total of 11,126 urine samples were received at Sultan Qaboos University Hospital (SQUH), Muscat, Sultanate of Oman, for one year period (2001), they were cultured for bacterial pathogen and sensitivity was performed for all significant isolates. Results: Eight hundred and eighty-four samples were culture positive with Escherichia coli (E.coli) (N=445) as the most common enterobacteriaceae, followed by Klebsiella pneumoniae (N=161), unidentified Coliforms (N=56) and Klebsiella species (N=33). High rate of resistance to β-Lactams was seen for all Enterobacteriaceae, maximum resistance was against ampicillin (78.6%) followed by co-amoxiclav (44.6%), but cefuroxime demonstrated the least resistance. Resistance to quinolone ranged from 4.7%-21.2% for all Enterobacteriaceae, cotrimoxazole resistance for all Enterobacteriaceae was 32.1%. Multi-drug resistance of E.coli was analyzed, 11.2% (50 of 445) were resistant to 3 or more antimicrobials and considered multidrug resistant. Among the multidrug-resistant isolates, 88% were resistant co-amoxiclav or cotrimoxazole, gentamicin 62%, ciprofloxacin 66%, and nitrofurantoin 32%. The predominant phenotype among multidrug-resistant isolates (26%; 13 of 50) included resistance to co-amoxiclav, gentamicin, and cotrimoxazole. This was the most common phenotype followed by 20%, of co-amoxiclav, cotrimoxazole and ciprofloxacin. Conclusion: In view of the current prevalence of multi-drug resistance among urinary tract isolates of E.coli at the SQUH (11.2%), continued surveillance will be beneficial.

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