Motor and behavioral effects of moringa oleifera leaf extract

Mohammed Al-Abri, Mohammed Ashique, Aishwarya Ramkumar, Abderrahim Nemmar, Badreldin Ali

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Moringa oleifera is a medicinal plant widely used in many parts of the world for hypertension, pain and epilepsy. The aim of this study was to determine the effect of M. oleifera aqueous leaf extract on motor and behavioral activities of healthy mice. Male mice were randomly divided into a control group (given 0.9% NaCl orally) and three groups treated with the extract at doses of 100, 200, and 400 mg/kg/day for 14 consecutive days. Motor and behavioral activity were evaluated by quantifying motor activity, exploration (hole-board), neuro-muscular coordination (rota rod treadmill), pain (hot plate, cold-water tail flick, and acetic acid-induced abdominal constriction), and depression (forced swimming test, FST). Administration of M. oleifera extract had a significant and dose-dependent antinociceptive action in both thermal and chemical tests (p < 0.05). The extract (400 mg/kg) caused a reduction in exploration activity and neuromuscular coordination, and decreased the mobility time in the FST, suggesting an antidepressant-like action. Motor activity was not significantly affected by any of the doses used. The results suggest that the plant aqueous extract may have a dose-dependent central nervous system (CNS) depressant action.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalNatural Product Communications
Volume13
Issue number1
Publication statusPublished - Jan 1 2018

Keywords

  • Analgesia
  • Behavior
  • Depressant-like action
  • Mice
  • Moringa oleifera
  • Moringaceae
  • Motor activity

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

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