Motivational deficits after brain injury

Effects of bromocriptine in 11 patients

J. H. Powell, S. Al-Adawi, J. Morgan, R. J. Greenwood

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Objective - To test the hypothesis that treatment with bromocriptine would ameliorate deficits in clinical motivation, responsiveness to reward, and frontal cognitive function after brain injury. Method - An open trial in six men and five women who had had either traumatic brain injury or subarachnoid haemorrhage between two months and five years previously. After repeated baseline assessments, bromocriptine was given in gradually increasing doses. Assessments were repeated at increasing doses, during maintenance, and after withdrawal. Novel structured instruments for quantifying motivation were developed; measures of anxiety and depression, and cognitive tests sensitive to motivation or frontal lobe involvement were also given. Results - Bromocriptine treatment was followed by improved scores on all measures other than mood. Improvement was maintained after bromocriptine withdrawal in eight of the patients. Conclusion - Poor motivation in patients with brain injury may result from dysfunction in the mesolimbic/mesocortical dopaminergic circuitry, giving rise to associated deficiencies in reward responsiveness and frontal cognitive function.

Original languageEnglish
Pages (from-to)416-421
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume60
Issue number4
Publication statusPublished - Apr 1996

Fingerprint

Bromocriptine
Brain Injuries
Motivation
Reward
Cognition
Traumatic Brain Hemorrhage
Traumatic Subarachnoid Hemorrhage
Frontal Lobe
Anxiety
Maintenance
Depression
Therapeutics

Keywords

  • Abulia
  • Bromocriptine
  • Dopamine
  • Motivation

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Motivational deficits after brain injury : Effects of bromocriptine in 11 patients. / Powell, J. H.; Al-Adawi, S.; Morgan, J.; Greenwood, R. J.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 60, No. 4, 04.1996, p. 416-421.

Research output: Contribution to journalArticle

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