Morphology of the human aorta and age-related changes: Anatomical facts

Pornhatai Komutrattananont, Pasuk Mahakkanukrauh*, Srijit Das

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)


Aorta is the largest artery in the human body. Its starting point is the aortic orifice of the aortic valve and it terminates at the level of the fourth lumbar vertebra. The main function of the aorta is to transport oxygenated blood to supply all the organs and cells. With advancing age, the structure and hence the function show progressive changes. Various changes in the aortic morphology include the luminal diameter of aorta, whole length of the aorta, thickness, the microstructural components also change, and these include collagen, elastin and smooth muscle cells. In addition, the dimensions of all segments of the aorta increase with age in both sexes. Since age is a major risk factor for degenerative change and diseases affecting the aorta, understanding the detailed anatomy of the aorta may provide essential information concerning the age-associated process of the aorta. Knowledge of the morphological changes in the aorta is also important for future clinical therapies pertaining to aortic disease. Additionally, the information regarding the structural changes with age may be applied for age determination. This review describes the overview of the anatomy of the aorta, age related changes in the morphology of the aorta and aortic diseases.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalAnatomy and Cell Biology
Issue number2
Publication statusPublished - Jun 1 2019


  • Abdominal aorta
  • Age change
  • Aorta
  • Thoracic aorta

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Developmental Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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