Monoclonal antibody imaging in patients with colorectal cancer and increasing levels of serum carcinoembryonic antigen. Experience with ZCE‐025 and IMMU‐4 monoclonal antibodies and proposed directions for clinical trials

Yehuda Z. Patt, Donald A. Podoloff, Stephen Curley, Ruth Smith, Vijaya A. Badkhamkar, Lamk M. Lamki, M. Milburn Jessup, David C. Hohn

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In an effort to identify the site of recurrent colorectal cancer in patients with occult metastasis and increasing serum CEA levels, we conducted two trials using monoclonal antibodies (MoAb) against CEA. The first utilized Indium‐111‐labeled ZCE‐025; an immunoglobulin G1 (IgG1) anticarcinoembryonic antigen (anti‐CEA) antibody (Hybritech, San Diego, CA). The second study used Tc‐99m‐labeled Fab' fragment of IMMU‐4 (Immunomedics, Morris Plains, NJ). Eighteen patients were imaged with the ZCE‐025 and 14 with the Tc‐99m Fab' IMMU‐4. True‐positive scans, defined as at least one correct correlation of the MoAb scan and surgical/histologic findings, were observed in 12 of 15 patients undergoing exploration or biopsy using the ZCE‐025 and 11 of 14 using the IMMU‐4. There were no true‐negative scans with the ZCE‐025 and only 2 of 14 with the IMMU‐4. There were 3 false‐positive scans with the ZCE‐025 and 1 of 14 with IMMU‐4. There were no false‐negative scans with either ZCE‐025 or IMMU‐4. Four (31%) of 13 patients undergoing exploration and imaged with ZCE‐025 and 5 (36%) of 14 imaged with IMMU‐4 had complete tumor resection. Treatment decisions were affected in 3 (16%) of 18 ZCE‐025‐imaged patients and 3 (21%) of 14 IMMU‐4 ones. Two (14%) of 14 patients imaged with IMMU‐4 had negative MoAb scans and negative laparotomies. Despite these findings, it is not known whether such early detection and resection will translate into improved survival rates. The authors suggest two randomized studies, one designed to ascertain the role of MoAb added to blind exploratory laparotomy. In that study, patients with increasing CEA levels and a negative workup will be randomized to an exploratory laparotomy preceded by MoAb anti‐CEA scans or a straight exploratory laparotomy without the assistance of a MoAb anti‐CEA scan. Endpoints will be differences in complete resectability and survival. A second study will examine the merits of blind exploratory laparotomies. In that study, patients with increasing CEA levels and a negative workup would be randomized to MoAb imaging, exploratory laparotomy, and radioimmuno‐guided surgery, and the other cohort of patients would continue to have conventional radiologic workup. Exploration in this latter group would be performed only when indicated by radiologic or endoscopic studies. The end‐point of the study would compare survival in the two cohorts of patients. These two studies may ultimately settle the debate regarding the correct approach to patients with occult metastatic colorectal cancer and a increasing levels of serum CEA.

Original languageEnglish
Pages (from-to)4293-4297
Number of pages5
JournalCancer
Volume71
Issue number12 S
DOIs
Publication statusPublished - 1993

Fingerprint

Carcinoembryonic Antigen
Colorectal Neoplasms
Monoclonal Antibodies
Clinical Trials
Laparotomy
Serum
Antigens
Direction compound
Immunoglobulin Fab Fragments
Survival
Immunoglobulins
Survival Rate
Neoplasm Metastasis
Biopsy

Keywords

  • colorectal cancer
  • immunoscintigraphy
  • IMMU‐4
  • increasing carcinoembryonic antigen
  • monoclonal antibodies
  • radioactive immunodiagnosis
  • ZCE‐025

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Monoclonal antibody imaging in patients with colorectal cancer and increasing levels of serum carcinoembryonic antigen. Experience with ZCE‐025 and IMMU‐4 monoclonal antibodies and proposed directions for clinical trials. / Patt, Yehuda Z.; Podoloff, Donald A.; Curley, Stephen; Smith, Ruth; Badkhamkar, Vijaya A.; Lamki, Lamk M.; Jessup, M. Milburn; Hohn, David C.

In: Cancer, Vol. 71, No. 12 S, 1993, p. 4293-4297.

Research output: Contribution to journalArticle

Patt, Yehuda Z. ; Podoloff, Donald A. ; Curley, Stephen ; Smith, Ruth ; Badkhamkar, Vijaya A. ; Lamki, Lamk M. ; Jessup, M. Milburn ; Hohn, David C. / Monoclonal antibody imaging in patients with colorectal cancer and increasing levels of serum carcinoembryonic antigen. Experience with ZCE‐025 and IMMU‐4 monoclonal antibodies and proposed directions for clinical trials. In: Cancer. 1993 ; Vol. 71, No. 12 S. pp. 4293-4297.
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abstract = "In an effort to identify the site of recurrent colorectal cancer in patients with occult metastasis and increasing serum CEA levels, we conducted two trials using monoclonal antibodies (MoAb) against CEA. The first utilized Indium‐111‐labeled ZCE‐025; an immunoglobulin G1 (IgG1) anticarcinoembryonic antigen (anti‐CEA) antibody (Hybritech, San Diego, CA). The second study used Tc‐99m‐labeled Fab' fragment of IMMU‐4 (Immunomedics, Morris Plains, NJ). Eighteen patients were imaged with the ZCE‐025 and 14 with the Tc‐99m Fab' IMMU‐4. True‐positive scans, defined as at least one correct correlation of the MoAb scan and surgical/histologic findings, were observed in 12 of 15 patients undergoing exploration or biopsy using the ZCE‐025 and 11 of 14 using the IMMU‐4. There were no true‐negative scans with the ZCE‐025 and only 2 of 14 with the IMMU‐4. There were 3 false‐positive scans with the ZCE‐025 and 1 of 14 with IMMU‐4. There were no false‐negative scans with either ZCE‐025 or IMMU‐4. Four (31{\%}) of 13 patients undergoing exploration and imaged with ZCE‐025 and 5 (36{\%}) of 14 imaged with IMMU‐4 had complete tumor resection. Treatment decisions were affected in 3 (16{\%}) of 18 ZCE‐025‐imaged patients and 3 (21{\%}) of 14 IMMU‐4 ones. Two (14{\%}) of 14 patients imaged with IMMU‐4 had negative MoAb scans and negative laparotomies. Despite these findings, it is not known whether such early detection and resection will translate into improved survival rates. The authors suggest two randomized studies, one designed to ascertain the role of MoAb added to blind exploratory laparotomy. In that study, patients with increasing CEA levels and a negative workup will be randomized to an exploratory laparotomy preceded by MoAb anti‐CEA scans or a straight exploratory laparotomy without the assistance of a MoAb anti‐CEA scan. Endpoints will be differences in complete resectability and survival. A second study will examine the merits of blind exploratory laparotomies. In that study, patients with increasing CEA levels and a negative workup would be randomized to MoAb imaging, exploratory laparotomy, and radioimmuno‐guided surgery, and the other cohort of patients would continue to have conventional radiologic workup. Exploration in this latter group would be performed only when indicated by radiologic or endoscopic studies. The end‐point of the study would compare survival in the two cohorts of patients. These two studies may ultimately settle the debate regarding the correct approach to patients with occult metastatic colorectal cancer and a increasing levels of serum CEA.",
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AU - Patt, Yehuda Z.

AU - Podoloff, Donald A.

AU - Curley, Stephen

AU - Smith, Ruth

AU - Badkhamkar, Vijaya A.

AU - Lamki, Lamk M.

AU - Jessup, M. Milburn

AU - Hohn, David C.

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