Modulatory effect of concomitant administration of insulin and vanadium on inflammatory biomarkers in type 2 diabetic rats: Role of adiponectin

Ismaeel Bin-Jaliah, Hussein F. Sakr, Mohamed D. Morsy, Mohamed Dallak, Mohamed A. Haidara*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The aim of this study is to investigate the effect of vanadium and/or insulin on the proinflammatory biomarkers in type 2 diabetes mellitus (T2DM) rat model. Sixty male Sprague Dawley rats were divided into six groups (n = 10). Control group, control vanadium group, T2DM group, insulin-treated diabetic group, vanadium-treated diabetic group, and concomitant insulin and vanadium-treated diabetic group. At the end of the experiment, serum glucose, insulin, lipid profile, tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), high sensitivity C reactive protein (hs- CRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and adiponectin were measured. Administration of insulin and/or vanadium significantly decreased in the plasma levels of glucose, lipid profile, TNF-α, IL-6, hs-CRP, ICAM-1, and VCAM-1 with significant increase in adiponectin in comparison to the diabetic group. Concomitant administration of insulin and vanadium significantly improved the above measured parameters compared to either insulin or vanadium treatment. Based on our results we can conclude that administration of both vanadium and insulin reduced the low-grade systemic inflammation in T2DM, through reduction of both proinflammatory cytokines and adhesion molecules and increase adiponectin.

Original languageEnglish
Pages (from-to)42-49
Number of pages8
JournalChinese Journal of Physiology
Volume61
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Adiponectin
  • Cytokines
  • Diabetes
  • Insulin
  • Vanadium

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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