Microwave-assisted palladium-catalyzed cross-coupling reactions: Generation of carbon–carbon bond

Kifah S.M. Salih*, Younis Baqi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Citations (SciVal)


Cross-coupling reactions furnishing carbon–carbon (C–C) bond is one of the most challenging tasks in organic syntheses. The early developed reaction protocols by Negishi, Heck, Kumada, Sonogashira, Stille, Suzuki, and Hiyama, utilizing palladium or its salts as catalysis have, for decades, attracted and inspired researchers affiliated with academia and industry. Tremendous efforts have been paid to develop and achieve more sustainable reaction conditions, such as the reduction in energy consumption by applying the microwave irradiation technique. Chemical reactions under controlled microwave conditions dramatically reduce the reaction time and therefore resulting in increase in the yield of the desired product by minimizing the formation of side products. In this review, we mainly focus on the recent advances and applications of palladium catalyzed cross-coupling carbon–carbon bond formation under microwave technology.

Original languageEnglish
Article number4
Issue number1
Publication statusPublished - Jan 2020


  • C-C bond formation
  • Cross-coupling reaction
  • Microwave
  • Pd catalysts

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry


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