MicroRNA as a biomarker for diagnostic, prognostic, and therapeutic purpose in urinary tract cancer

Amro M. Soliman; Mohamed Soliman; Srijit Das; Seong Lin Teoh

doi:10.3390/pr9122136

MicroRNA as a biomarker for diagnostic, prognostic, and therapeutic purpose in urinary tract cancer

Amro M. Soliman, Mohamed Soliman, Srijit Das^*, Seong Lin Teoh^*

^*Corresponding author for this work

Human & Clinical Anatomy

Research output: Contribution to journal › Review article › peer-review

Abstract

The incidence of urologic cancers, including kidney, upper tract urothelial, and bladder malignancies, is increasing globally, with a high percentage of cases showing metastasis upon diagnosis and low five-year survival rates. MicroRNA (miRNA), a small non-coding RNA, was found to regulate the expression of oncogenes and tumor suppressor genes in several tumors, including cancers of the urinary system. In the current review, we comprehensively discuss the recently reported up-or down-regulated miRNAs as well as their possible targets and regulated pathways involved in the development, progression, and metastasis of urinary tract cancers. These miRNAs represent potential therapeutic targets and diagnostic/prognostic biomarkers that may help in efficient and early diagnosis in addition to better treatment outcomes.

Original language	English
Article number	2136
Journal	Processes
Volume	9
Issue number	12
DOIs	https://doi.org/10.3390/pr9122136
Publication status	Published - Dec 2021

Keywords

Diagnosis
MiRNA
Prognosis
Renal-cell carcinoma
Therapeutic targets
Upper tract urothelial carcinoma
Urinary bladder cancer

ASJC Scopus subject areas

Bioengineering
Chemical Engineering (miscellaneous)
Process Chemistry and Technology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/pr9122136

Cite this

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title = "MicroRNA as a biomarker for diagnostic, prognostic, and therapeutic purpose in urinary tract cancer",

abstract = "The incidence of urologic cancers, including kidney, upper tract urothelial, and bladder malignancies, is increasing globally, with a high percentage of cases showing metastasis upon diagnosis and low five-year survival rates. MicroRNA (miRNA), a small non-coding RNA, was found to regulate the expression of oncogenes and tumor suppressor genes in several tumors, including cancers of the urinary system. In the current review, we comprehensively discuss the recently reported up-or down-regulated miRNAs as well as their possible targets and regulated pathways involved in the development, progression, and metastasis of urinary tract cancers. These miRNAs represent potential therapeutic targets and diagnostic/prognostic biomarkers that may help in efficient and early diagnosis in addition to better treatment outcomes.",

keywords = "Diagnosis, MiRNA, Prognosis, Renal-cell carcinoma, Therapeutic targets, Upper tract urothelial carcinoma, Urinary bladder cancer",

author = "Soliman, {Amro M.} and Mohamed Soliman and Srijit Das and Teoh, {Seong Lin}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = dec,

doi = "10.3390/pr9122136",

language = "English",

volume = "9",

journal = "Processes",

issn = "2227-9717",

publisher = "MDPI AG",

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T1 - MicroRNA as a biomarker for diagnostic, prognostic, and therapeutic purpose in urinary tract cancer

AU - Soliman, Amro M.

AU - Soliman, Mohamed

AU - Das, Srijit

AU - Teoh, Seong Lin

PY - 2021/12

Y1 - 2021/12

N2 - The incidence of urologic cancers, including kidney, upper tract urothelial, and bladder malignancies, is increasing globally, with a high percentage of cases showing metastasis upon diagnosis and low five-year survival rates. MicroRNA (miRNA), a small non-coding RNA, was found to regulate the expression of oncogenes and tumor suppressor genes in several tumors, including cancers of the urinary system. In the current review, we comprehensively discuss the recently reported up-or down-regulated miRNAs as well as their possible targets and regulated pathways involved in the development, progression, and metastasis of urinary tract cancers. These miRNAs represent potential therapeutic targets and diagnostic/prognostic biomarkers that may help in efficient and early diagnosis in addition to better treatment outcomes.

AB - The incidence of urologic cancers, including kidney, upper tract urothelial, and bladder malignancies, is increasing globally, with a high percentage of cases showing metastasis upon diagnosis and low five-year survival rates. MicroRNA (miRNA), a small non-coding RNA, was found to regulate the expression of oncogenes and tumor suppressor genes in several tumors, including cancers of the urinary system. In the current review, we comprehensively discuss the recently reported up-or down-regulated miRNAs as well as their possible targets and regulated pathways involved in the development, progression, and metastasis of urinary tract cancers. These miRNAs represent potential therapeutic targets and diagnostic/prognostic biomarkers that may help in efficient and early diagnosis in addition to better treatment outcomes.

KW - Diagnosis

KW - MiRNA

KW - Prognosis

KW - Renal-cell carcinoma

KW - Therapeutic targets

KW - Upper tract urothelial carcinoma

KW - Urinary bladder cancer

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DO - 10.3390/pr9122136

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JF - Processes

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ER -

MicroRNA as a biomarker for diagnostic, prognostic, and therapeutic purpose in urinary tract cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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