Micro-RNA and the features of metabolic syndrome: A narrative review

Srijit Das*, Isa Naina Mohamed, Seong Lin Teoh, Tarrsini Thevaraj, Ku Nurmahirah Ku Ahmad Nasir, Azwani Zawawi, Hazwan Hazrin Salim, Dennis Kheng Zhou

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

The incidence of metabolic syndrome (MetS) has risen globally. MetS includes a combination of features, i.e. blood glucose impairment, excess abdominal/body fat dyslipidemia and elevated blood pressure. Other than conventional treatment with drugs, the main preventive approaches include lifestyle changes, weight loss, diet control and adequate exercise also proves to be beneficial. MicroRNAs (miRNAs) are small non-coding RNAs that play critical regulatory roles in most biological and pathological processes. In the present review, we discuss various miRNAs which are related to MetS by targeting various organs, including the pancreas, liver, skeletal muscles and adipose tissues. These miRNAs have the effect on insulin production and secretion (miR-9, miR-124a, miR-130a,b, miR152, miR-335, miR-375), insulin resistance (miR-29), adipogenesis (miR-143, miR148a) and lipid metabolism (miR-192). We also discuss the miRNAs as potential biomarkers and future therapeutic targets. This review may be beneficial for molecular biologists and clinicians dealing with MetS.

Original languageEnglish
Pages (from-to)626-635
Number of pages10
JournalMini-Reviews in Medicinal Chemistry
Volume20
Issue number7
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Biomarker
  • Metabolic syndrome
  • MetS
  • MiRNA
  • RNAs
  • Therapeutic

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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