Micro-ribonucleic acid and carcinogenesis: Breast cancer as an example

Manal Al-Khanbashi, Mansour Al-Moundhri

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs that have unique functions at post-transcriptional level (epigenetics). MiRNAs play a pivotal role in controlling gene expression at various levels including differentiation, cell-cycle regulation, apoptosis and many others in mammals as well as in many organisms. Recently, there has been greater understanding of the contribution of dysregulation of miRNA into disease status in particular carcinogenesis. In this review, we will discuss miRNA discovery, nomenclature, function, contribution of their dysregulation into disease status in particular carcinogenesis and their potential role as biomarkers.

Original languageEnglish
Pages (from-to)28-34
Number of pages7
JournalOncology Reviews
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

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Keywords

  • Breast cancer
  • miRNA
  • Neo-adjuvant chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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