Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma

Hasen M. Alhebshi, Ishita Pant, Gurjeet Kaur, Hasnah Hashim, Mohamed J E M F Mabruk

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The methylthioadenosine phosphorylase (MTAP) gene is a tumour suppressor gene, located on chromosome 9p21, 100 kb telomeric of the p15 and p16 genes, which are often deleted in tumor cells. The role of MTAP protein expression in the genesis of cutaneous squamous cell carcinoma (SCC) is currently not known. In a previous study we have shown the frequent occurrence of allelic imbalance / loss of heterozygosity (AI/LOH) in cutaneous SCCs using AI/LOH markers flanking the p15, p16, and MTAP genes and demonstrated reduction in p15 and p16 protein expression in comparison to normal human skin. The present study is a continuation to our previous studies, aimed at determining possible roles played by MTAP protein expression in the genesis of cutaneous SCC. The expression of MTAP protein was detected using immunohistochemical approach in 109 micro array cutaneous SCC and 20 normal human skin tissue samples. The expression of MTAP was not significantly different in the cutaneous SCC cases as compared with normal human skin. This may indicate that MTAP protein expression does not contribute to the genesis of cutaneous SCC.

Original languageEnglish
Pages (from-to)291-294
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume9
Issue number2
Publication statusPublished - 2008

Fingerprint

Squamous Cell Carcinoma
Skin
Loss of Heterozygosity
Allelic Imbalance
Proteins
p16 Genes
5'-methylthioadenosine phosphorylase
Tumor Suppressor Genes
Genes
Chromosomes
Neoplasms

Keywords

  • Cutaneous SSC
  • Immunohistochemistry
  • MTAP

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma. / Alhebshi, Hasen M.; Pant, Ishita; Kaur, Gurjeet; Hashim, Hasnah; Mabruk, Mohamed J E M F.

In: Asian Pacific Journal of Cancer Prevention, Vol. 9, No. 2, 2008, p. 291-294.

Research output: Contribution to journalArticle

Alhebshi, Hasen M. ; Pant, Ishita ; Kaur, Gurjeet ; Hashim, Hasnah ; Mabruk, Mohamed J E M F. / Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma. In: Asian Pacific Journal of Cancer Prevention. 2008 ; Vol. 9, No. 2. pp. 291-294.
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