Metabolic normalization of α-ketoglutarate against N-nitrosodiethylamine-induced hepatocarcinogenesis in rats

K. B. Dakshayani; P. Subramanian; T. Manivasagam; M. Mohamed Essa

doi:10.1111/j.1472-8206.2006.00422.x

Metabolic normalization of α-ketoglutarate against N-nitrosodiethylamine-induced hepatocarcinogenesis in rats

K. B. Dakshayani, P. Subramanian^*, T. Manivasagam, M. Mohamed Essa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Chemoprevention of cancer is one of the reliable approaches to control the incidence of cancer. In the present study, we investigated the chemopreventive role of α-ketoglutarate (α-KG) during N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis. The activities of serum aspartate and alanine transaminases were found to be significantly higher in NDEA + CCl ₄-treated animals when compared with control animals. Administration of α-KG restored the activities of transaminases to near normal range. The levels of lipid peroxides, thiobarbituric acid reactive substances were decreased in the liver tissue of NDEA + CCl₄-treated animals when compared with control animals. α-KG reversed the lipid peroxide levels to near normal range. Levels of antioxidants, reduced glutathione and activities of its dependent enzymes, glutathione peroxidase and glutathione-S-transferase were found to be significantly higher in liver tissue of NDEA + CCl ₄-treated animals when compared with control animals. α-KG administration positively modulated the antioxidant levels to near normal range. In conclusion, it can be suggested that α-KG exerts chemopreventive role which may attributable to its ability to positively modulate the transaminase activities and oxidant-antioxidant imbalance during hepatocarcinogenesis.

Original language	English
Pages (from-to)	477-480
Number of pages	4
Journal	Fundamental and Clinical Pharmacology
Volume	20
Issue number	5
DOIs	https://doi.org/10.1111/j.1472-8206.2006.00422.x
Publication status	Published - Oct 2006
Externally published	Yes

Keywords

Antioxidants
Hepatocellular carcinoma
Lipid peroxides
α-ketoglutarate

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1472-8206.2006.00422.x

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title = "Metabolic normalization of α-ketoglutarate against N-nitrosodiethylamine-induced hepatocarcinogenesis in rats",

abstract = "Chemoprevention of cancer is one of the reliable approaches to control the incidence of cancer. In the present study, we investigated the chemopreventive role of α-ketoglutarate (α-KG) during N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis. The activities of serum aspartate and alanine transaminases were found to be significantly higher in NDEA + CCl 4-treated animals when compared with control animals. Administration of α-KG restored the activities of transaminases to near normal range. The levels of lipid peroxides, thiobarbituric acid reactive substances were decreased in the liver tissue of NDEA + CCl4-treated animals when compared with control animals. α-KG reversed the lipid peroxide levels to near normal range. Levels of antioxidants, reduced glutathione and activities of its dependent enzymes, glutathione peroxidase and glutathione-S-transferase were found to be significantly higher in liver tissue of NDEA + CCl 4-treated animals when compared with control animals. α-KG administration positively modulated the antioxidant levels to near normal range. In conclusion, it can be suggested that α-KG exerts chemopreventive role which may attributable to its ability to positively modulate the transaminase activities and oxidant-antioxidant imbalance during hepatocarcinogenesis.",

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author = "Dakshayani, {K. B.} and P. Subramanian and T. Manivasagam and {Mohamed Essa}, M.",

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AU - Manivasagam, T.

AU - Mohamed Essa, M.

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N2 - Chemoprevention of cancer is one of the reliable approaches to control the incidence of cancer. In the present study, we investigated the chemopreventive role of α-ketoglutarate (α-KG) during N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis. The activities of serum aspartate and alanine transaminases were found to be significantly higher in NDEA + CCl 4-treated animals when compared with control animals. Administration of α-KG restored the activities of transaminases to near normal range. The levels of lipid peroxides, thiobarbituric acid reactive substances were decreased in the liver tissue of NDEA + CCl4-treated animals when compared with control animals. α-KG reversed the lipid peroxide levels to near normal range. Levels of antioxidants, reduced glutathione and activities of its dependent enzymes, glutathione peroxidase and glutathione-S-transferase were found to be significantly higher in liver tissue of NDEA + CCl 4-treated animals when compared with control animals. α-KG administration positively modulated the antioxidant levels to near normal range. In conclusion, it can be suggested that α-KG exerts chemopreventive role which may attributable to its ability to positively modulate the transaminase activities and oxidant-antioxidant imbalance during hepatocarcinogenesis.

AB - Chemoprevention of cancer is one of the reliable approaches to control the incidence of cancer. In the present study, we investigated the chemopreventive role of α-ketoglutarate (α-KG) during N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis. The activities of serum aspartate and alanine transaminases were found to be significantly higher in NDEA + CCl 4-treated animals when compared with control animals. Administration of α-KG restored the activities of transaminases to near normal range. The levels of lipid peroxides, thiobarbituric acid reactive substances were decreased in the liver tissue of NDEA + CCl4-treated animals when compared with control animals. α-KG reversed the lipid peroxide levels to near normal range. Levels of antioxidants, reduced glutathione and activities of its dependent enzymes, glutathione peroxidase and glutathione-S-transferase were found to be significantly higher in liver tissue of NDEA + CCl 4-treated animals when compared with control animals. α-KG administration positively modulated the antioxidant levels to near normal range. In conclusion, it can be suggested that α-KG exerts chemopreventive role which may attributable to its ability to positively modulate the transaminase activities and oxidant-antioxidant imbalance during hepatocarcinogenesis.

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KW - Hepatocellular carcinoma

KW - Lipid peroxides

KW - α-ketoglutarate

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Metabolic normalization of α-ketoglutarate against N-nitrosodiethylamine-induced hepatocarcinogenesis in rats

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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