Metabolic normalization of α-ketoglutarate against N-nitrosodiethylamine-induced hepatocarcinogenesis in rats

K. B. Dakshayani, P. Subramanian, T. Manivasagam, M. Mohamed Essa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chemoprevention of cancer is one of the reliable approaches to control the incidence of cancer. In the present study, we investigated the chemopreventive role of α-ketoglutarate (α-KG) during N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis. The activities of serum aspartate and alanine transaminases were found to be significantly higher in NDEA + CCl 4-treated animals when compared with control animals. Administration of α-KG restored the activities of transaminases to near normal range. The levels of lipid peroxides, thiobarbituric acid reactive substances were decreased in the liver tissue of NDEA + CCl4-treated animals when compared with control animals. α-KG reversed the lipid peroxide levels to near normal range. Levels of antioxidants, reduced glutathione and activities of its dependent enzymes, glutathione peroxidase and glutathione-S-transferase were found to be significantly higher in liver tissue of NDEA + CCl 4-treated animals when compared with control animals. α-KG administration positively modulated the antioxidant levels to near normal range. In conclusion, it can be suggested that α-KG exerts chemopreventive role which may attributable to its ability to positively modulate the transaminase activities and oxidant-antioxidant imbalance during hepatocarcinogenesis.

Original languageEnglish
Pages (from-to)477-480
Number of pages4
JournalFundamental and Clinical Pharmacology
Volume20
Issue number5
DOIs
Publication statusPublished - Oct 2006

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Keywords

  • α-ketoglutarate
  • Antioxidants
  • Hepatocellular carcinoma
  • Lipid peroxides

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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