Chemoprevention of cancer is one of the reliable approaches to control the incidence of cancer. In the present study, we investigated the chemopreventive role of α-ketoglutarate (α-KG) during N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis. The activities of serum aspartate and alanine transaminases were found to be significantly higher in NDEA + CCl 4-treated animals when compared with control animals. Administration of α-KG restored the activities of transaminases to near normal range. The levels of lipid peroxides, thiobarbituric acid reactive substances were decreased in the liver tissue of NDEA + CCl4-treated animals when compared with control animals. α-KG reversed the lipid peroxide levels to near normal range. Levels of antioxidants, reduced glutathione and activities of its dependent enzymes, glutathione peroxidase and glutathione-S-transferase were found to be significantly higher in liver tissue of NDEA + CCl 4-treated animals when compared with control animals. α-KG administration positively modulated the antioxidant levels to near normal range. In conclusion, it can be suggested that α-KG exerts chemopreventive role which may attributable to its ability to positively modulate the transaminase activities and oxidant-antioxidant imbalance during hepatocarcinogenesis.
|Number of pages||4|
|Journal||Fundamental and Clinical Pharmacology|
|Publication status||Published - Oct 2006|
- Hepatocellular carcinoma
- Lipid peroxides
ASJC Scopus subject areas
- Pharmacology (medical)