Megestrol acetate promotes euglycemia and appetite in a child with persistent hyperinsulinemic hypoglycemia of infancy

S. Alyaarubi, M. Ramsay, C. Rodd

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This report describes a successful treatment with megestrol acetate in a child with persistent hyperinsulinemic hypoglycemia of infancy (PHHI). An 8-y-old child with PHHI treated with octreotide had marked impairment of appetite sensation and feeding skills. Within 3 wk of starting megestrol acetate (8 mg/kg/d) to stimulate her appetite, she had a significant improvement. By 1 y postinitiation, she had acquired age-appropriate eating habits. The megestrol acetate caused hyperglycemia, necessitating the discontinuation of all other therapy for her hypoglycemia. Her height growth remained normal but she was found to have asymptomatic adrenal suppression. Conclusion: Megestrol acetate appeared to stimulate appetite and regulate glucose homeostasis in this child with PHHI. Additional studies will be required to document its efficacy and safety in other children with this disorder.

Original languageEnglish
Pages (from-to)422-423
Number of pages2
JournalActa Paediatrica, International Journal of Paediatrics
Volume93
Issue number3
DOIs
Publication statusPublished - Mar 2004

Fingerprint

Congenital Hyperinsulinism
Megestrol Acetate
Appetite
Octreotide
Feeding Behavior
Hypoglycemia
Hyperglycemia
Homeostasis
Safety
Glucose
Therapeutics
Growth

Keywords

  • Euglycemia
  • Megestrol acetate
  • Persistent hyperinsulinemic hypoglycemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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AB - This report describes a successful treatment with megestrol acetate in a child with persistent hyperinsulinemic hypoglycemia of infancy (PHHI). An 8-y-old child with PHHI treated with octreotide had marked impairment of appetite sensation and feeding skills. Within 3 wk of starting megestrol acetate (8 mg/kg/d) to stimulate her appetite, she had a significant improvement. By 1 y postinitiation, she had acquired age-appropriate eating habits. The megestrol acetate caused hyperglycemia, necessitating the discontinuation of all other therapy for her hypoglycemia. Her height growth remained normal but she was found to have asymptomatic adrenal suppression. Conclusion: Megestrol acetate appeared to stimulate appetite and regulate glucose homeostasis in this child with PHHI. Additional studies will be required to document its efficacy and safety in other children with this disorder.

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