Mechanisms of induction of skin cancer by UV radiation.

H. Soehnge, A. Ouhtit, O. N. Ananthaswamy

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Ultraviolet (UV) radiation is the carcinogenic factor in sunlight; damage to skin cells from repeated exposure can lead to the development of cancer. UV radiation has been mainly implicated as the cause of non-melanoma skin cancer, although some role for UV in malignant melanoma has been suggested. The induction of skin cancer is mainly caused by the accumulation of mutations caused by UV damage. Cellular mechanisms exist to repair the DNA damage, or to induce apoptosis to remove severely damaged cells; however, the additive effects of mutations in genes involved in these mechanisms, or in control of the cell cycle, can lead to abnormal cell proliferation and tumor development. The molecular events in the induction of skin cancer are being actively investigated, and recent research has added to the understanding of the roles of tumor suppressor and oncogenes in skin cancer. UV radiation has been shown to induce the expression of the p53 tumor suppressor gene, and is known to produce "signature" mutations in p53 in human and mouse skin cancers and in the tumor suppressor gene patched in human basal cell carcinoma. The role of UV radiation in suppression of immune surveillance in the skin, which is an important protection against skin tumor development, is also being investigated. The knowledge gained will help to better understand the ways in which skin cancer arises from UV exposure, which will in turn allow development of better methods of treatment and prevention.

Original languageEnglish
JournalFrontiers in Bioscience
Volume2
Publication statusPublished - 1997

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Skin Neoplasms
Ultraviolet radiation
Skin
Radiation
Tumors
Tumor Suppressor Genes
Neoplasms
Genes
Mutation
Sunlight
Basal Cell Carcinoma
Cell Cycle Checkpoints
Oncogenes
Cells
DNA Damage
Melanoma
Cell Proliferation
Cell proliferation
Apoptosis
Repair

Cite this

Soehnge, H., Ouhtit, A., & Ananthaswamy, O. N. (1997). Mechanisms of induction of skin cancer by UV radiation. Frontiers in Bioscience, 2.

Mechanisms of induction of skin cancer by UV radiation. / Soehnge, H.; Ouhtit, A.; Ananthaswamy, O. N.

In: Frontiers in Bioscience, Vol. 2, 1997.

Research output: Contribution to journalArticle

Soehnge, H, Ouhtit, A & Ananthaswamy, ON 1997, 'Mechanisms of induction of skin cancer by UV radiation.', Frontiers in Bioscience, vol. 2.
Soehnge, H. ; Ouhtit, A. ; Ananthaswamy, O. N. / Mechanisms of induction of skin cancer by UV radiation. In: Frontiers in Bioscience. 1997 ; Vol. 2.
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