Mechanisms of host resistance against HIV infection and progression to AIDS

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Since the discovery in the early eighties of the Human Immunodeficiency Virus (HIV) that causes acquired immunodeficiency syndrome (AIDS), there have been reports of people who were completely resistant to infection with HIV and others who progressed at slower rates to AIDS. The present article summarises the mechanisms involved in resistance against HIV infection and progression to AIDS. The paper will specifically focus on the role of immunological mechanisms, genetics, ethnicity and cultural practices such as male circumcision in mitigating infection. The current understanding on host natural resistance against HIV infection and progression to AIDS would potentially contribute to better prevention strategies, delayed onset of AIDS in people living with HIV, the identification of more efficient types of therapy for AIDS patients and, possibly, appropriate vaccines against HIV/AIDS. This area of research has important implications for patient care through controlling factors that contribute to AIDS progression.

Original languageEnglish
Pages (from-to)83-96
Number of pages14
JournalSultan Qaboos University Medical Journal
Volume7
Issue number2
Publication statusPublished - Aug 1 2007

Fingerprint

Virus Diseases
Acquired Immunodeficiency Syndrome
HIV
Male Circumcision
Infection
Innate Immunity
Patient Care
Vaccines
Research

Keywords

  • AIDS
  • Disease
  • HIV
  • Natural
  • Progression
  • Resistance

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mechanisms of host resistance against HIV infection and progression to AIDS. / Al-Jabri, Ali A.

In: Sultan Qaboos University Medical Journal, Vol. 7, No. 2, 01.08.2007, p. 83-96.

Research output: Contribution to journalReview article

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