Marine derived bioactive compounds for treatment of Alzheimer’s disease

Sreeja Lakshmi, Parvathi Prakash, Mohamed Musthafa Essa, Walid M. Qoronfleh, Mohammed Akbar, Byoung Joon Song, Suresh S. Kumar, Preetham Elumalai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Alzheimer’s disease (AD) is mounting as social and economic encumbrance which are accompanied by deficits in cognition and memory. Over the past decades, Alzheimer’s disease (AD) holds the frontline as one of the biggest healthcare issues in the world. AD is an age related neurodegenerative disorder marked by a decline in memory and an impairment of cognition. Inspite of tedious scientific effort, AD is still devoid of pharmacotherapeutic strategies for treatment as well as prevention. Current treatment strategies using drugs are symbolic in nature as they treat disease manifestation though are found effective in treating cognition. Inclination of science towards naturopathic treatments aiming at preventing the disease is highly vocal. Application of marine-derived bioactive compounds, has been gaining attention as mode of therapies against AD. Inspired by the vastness and biodiversity richness of the marine environment, role of marine metabolites in developing new therapies targeting brain with special emphasis to neurodegeneration is heading as an arable field. This review summarizes select-few examples highlighted as therapeutical applications for neurodegenerative disorders with special emphasis on AD.

Original languageEnglish
Pages (from-to)537-548
Number of pages12
JournalFrontiers in Bioscience - Elite
Volume10
Issue number3
Publication statusPublished - Jun 1 2018

Keywords

  • Alzheimer’s disease
  • Marine Drugs
  • Neuroinflammation
  • Oxidative Stress
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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