Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson's disease mice

Mani Kavitha, Jagatheesan Nataraj, Musthafa Mohammed Essa, Mushtaq A. Memon, Thamilarasan Manivasagam

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Mangiferin, a polyphenol compound of C-glucoside, is well-known for its anti-inflammatory, antioxidant, anticancer, antidiabetic and cognitive enhancement properties. In this study, we investigated the neuroprotective effect of mangiferin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD), which is most popular and widely used to evaluate therapeutic implications of new protective agents. Male C57BL/6 mice were orally treated with mangiferin (10, 20 and 40 mg/kg body wt.) for 14 days and from 10th day onwards MPTP (30 mg/kg, i.p.) was injected for last 5 days. MPTP treatment leads to enhanced oxidative stress, induction of apoptosis (upregulates the expression of Bax, proapoptotic protein and downregulates the expression of anti-apoptotic marker Bcl-2), and loss of dopominergic neurons which results in motor impairments. Results of our study confirmed that mangiferin prevented MPTP-induced behavioral deficits, oxidative stress, apoptosis, dopaminergic neuronal degeneration and dopamine depletion. Taken together, we conclude that mangiferin attenuates the dopaminergic neurodegeneration mainly through its potent antioxidant and antiapoptotic properties.

Original languageEnglish
Pages (from-to)239-247
Number of pages9
JournalChemico-Biological Interactions
Volume206
Issue number2
DOIs
Publication statusPublished - 2013

Fingerprint

Parkinsonian Disorders
Oxidation-Reduction
Oxidative stress
Oxidative Stress
Antioxidants
Apoptosis
Protective Agents
bcl-2-Associated X Protein
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Glucosides
Polyphenols
Neuroprotective Agents
Inbred C57BL Mouse
Hypoglycemic Agents
Neurons
Parkinson Disease
Dopamine
Anti-Inflammatory Agents
Up-Regulation
Down-Regulation

Keywords

  • Anti-apoptosis
  • Behavior
  • Experimental Parkinson's disease
  • Mangiferin
  • Oxidative stress

ASJC Scopus subject areas

  • Toxicology

Cite this

Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson's disease mice. / Kavitha, Mani; Nataraj, Jagatheesan; Essa, Musthafa Mohammed; Memon, Mushtaq A.; Manivasagam, Thamilarasan.

In: Chemico-Biological Interactions, Vol. 206, No. 2, 2013, p. 239-247.

Research output: Contribution to journalArticle

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