Manganese-catalyzed directed methylation of C(sp2)-H bonds at 25 °C with high catalytic turnover

Takenari Sato, Takumi Yoshida, Hamad H. Al Mamari, Laurean Ilies, Eiichi Nakamura

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We report here a manganese-catalyzed C-H methylation reaction of considerable substrate scope, using MeMgBr, a catalytic amount of MnCl2· 2LiCl, and an organic dihalide oxidant. The reaction features ambient temperature, low catalyst loading, typically 1%, high catalytic turnover reaching 5.9 × 103, and no need for an extraneous ligand and illustrates a unique catalytic use of simple manganese salts for C-H activation, which so far has relied on catalysis by manganese carbonyls.

Original languageEnglish
Pages (from-to)5458-5461
Number of pages4
JournalOrganic Letters
Volume19
Issue number19
DOIs
Publication statusPublished - 2017

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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