Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine

Nader I. Al-Dewik*, Salma N. Younes, Musthafa Mohamed Essa, Surajit Pathak, M. Walid Qoronfleh

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Translational medicine, the exchange between laboratory (bench) and the clinic (bedside), is decidedly taking on a vital role. Many companies are now focusing on a translational medicinal approach as a therapeutic strategy in decision making upon realizing the expenses of drug attrition in late-stage advancement. In addition, the utility of biomarkers in clinical decision and therapy guidance seeks to improve the patient outcomes and decrease wasteful and harmful treatment. Efficient biomarkers are crucial for the advancement of diagnoses, better molecular targeted therapy, along with therapeutic advantages in a broad spectrum of various diseases. Despite recent advances in the discovery of biomarkers, the advancement route to a clinically validated biomarker remains intensely challenging, and many of the candidate biomarkers do not progress to clinical applications, thereby widening the innovation gap between research and application. The present article will focus on the clinical view of biomarkers in a reverse design, addressing how a biomarker program should appear if it is expected to create an impact on personalized medicine and patient care.

Original languageEnglish
Article number1107
JournalProcesses
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2022

Keywords

  • biomarkers
  • cancer
  • clinical trials
  • companion diagnostics
  • personalized medicine
  • precision medicine
  • therapy
  • translational medicine

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Process Chemistry and Technology

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