Maghemite (γ‐fe2o3) and γ‐fe2o3‐tio2 nanoparticles for magnetic hyperthermia applications: Synthesis, characterization and heating efficiency

O. M. Lemine*, Nawal Madkhali, Marzook Alshammari, Saja Algessair, Abbasher Gismelseed, Lassad El Mir, Moktar Hjiri, Ali A. Yousif, Kheireddine El‐boubbou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


In this report, the heating efficiencies of γ‐Fe2O3 and hybrid γ‐Fe2O3‐TiO2 nanoparticles NPs under an alternating magnetic field (AMF) have been investigated to evaluate their feasible use in magnetic hyperthermia. The NPs were synthesized by a modified sol‐gel method and characterized by different techniques. X‐ray diffraction (XRD), Mössbauer spectroscopy and electron micros-copy analyses confirmed the maghemite (γ‐Fe2O3) phase, crystallinity, good uniformity and 10 nm core sizes of the as‐synthesized composites. SQUID hysteresis loops showed a non‐negligible coer-cive field and remanence suggesting the ferromagnetic behavior of the particles. Heating efficiency measurements showed that both samples display high heating potentials and reached magnetic hyperthermia (42 °C) in relatively short times with shorter time (~3 min) observed for γ‐Fe2O3 com-pared to γ‐Fe2O3‐TiO2. The specific absorption rate (SAR) values calculated for γ‐Fe2O3 (up to 90 W/g) are higher than that for γ‐Fe2O3‐TiO2 (~40 W/g), confirming better heating efficiency for γ‐Fe2O3 NPs. The intrinsic loss power (ILP) values of 1.57 nHm2/kg and 0.64 nHm2/kg obtained for both nanocomposites are in the range reported for commercial ferrofluids (0.2–3.1 nHm2/kg). Finally, the heating mechanism responsible for NP heat dissipation is explained concluding that both Neel and Brownian relaxations are contributing to heat production. Overall, the obtained high heating efficiencies suggest that the fabricated nanocomposites hold a great potential to be utilized in a wide spectrum of applications, particularly in magnetic photothermal hyperthermia treatments.

Original languageEnglish
Article number5691
Issue number19
Publication statusPublished - Oct 1 2021


  • Alternating magnetic field
  • Heating efficiency
  • Iron oxide nanoparticles
  • Maghemite
  • Magnetic hyperthermia
  • Sol‐Gel synthesis
  • TiO2

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics


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