TY - JOUR
T1 - Maghemite (γ‐fe2o3) and γ‐fe2o3‐tio2 nanoparticles for magnetic hyperthermia applications
T2 - Synthesis, characterization and heating efficiency
AU - Lemine, O. M.
AU - Madkhali, Nawal
AU - Alshammari, Marzook
AU - Algessair, Saja
AU - Gismelseed, Abbasher
AU - Mir, Lassad El
AU - Hjiri, Moktar
AU - Yousif, Ali A.
AU - El‐boubbou, Kheireddine
N1 - Funding Information:
Acknowledgments: This research was supported by the Deanship of Scientific Research, Imam Mo‐ hammad Ibn Saud Islamic University (IMISU), Saudi Arabia, Grant No (19‐12‐12‐018).
Funding Information:
This research was supported by the Deanship of Scientific Research, Imam Mohammad Ibn Saud Islamic University (IMISU), Saudi Arabia, Grant No (19?12?12?018).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - In this report, the heating efficiencies of γ‐Fe2O3 and hybrid γ‐Fe2O3‐TiO2 nanoparticles NPs under an alternating magnetic field (AMF) have been investigated to evaluate their feasible use in magnetic hyperthermia. The NPs were synthesized by a modified sol‐gel method and characterized by different techniques. X‐ray diffraction (XRD), Mössbauer spectroscopy and electron micros-copy analyses confirmed the maghemite (γ‐Fe2O3) phase, crystallinity, good uniformity and 10 nm core sizes of the as‐synthesized composites. SQUID hysteresis loops showed a non‐negligible coer-cive field and remanence suggesting the ferromagnetic behavior of the particles. Heating efficiency measurements showed that both samples display high heating potentials and reached magnetic hyperthermia (42 °C) in relatively short times with shorter time (~3 min) observed for γ‐Fe2O3 com-pared to γ‐Fe2O3‐TiO2. The specific absorption rate (SAR) values calculated for γ‐Fe2O3 (up to 90 W/g) are higher than that for γ‐Fe2O3‐TiO2 (~40 W/g), confirming better heating efficiency for γ‐Fe2O3 NPs. The intrinsic loss power (ILP) values of 1.57 nHm2/kg and 0.64 nHm2/kg obtained for both nanocomposites are in the range reported for commercial ferrofluids (0.2–3.1 nHm2/kg). Finally, the heating mechanism responsible for NP heat dissipation is explained concluding that both Neel and Brownian relaxations are contributing to heat production. Overall, the obtained high heating efficiencies suggest that the fabricated nanocomposites hold a great potential to be utilized in a wide spectrum of applications, particularly in magnetic photothermal hyperthermia treatments.
AB - In this report, the heating efficiencies of γ‐Fe2O3 and hybrid γ‐Fe2O3‐TiO2 nanoparticles NPs under an alternating magnetic field (AMF) have been investigated to evaluate their feasible use in magnetic hyperthermia. The NPs were synthesized by a modified sol‐gel method and characterized by different techniques. X‐ray diffraction (XRD), Mössbauer spectroscopy and electron micros-copy analyses confirmed the maghemite (γ‐Fe2O3) phase, crystallinity, good uniformity and 10 nm core sizes of the as‐synthesized composites. SQUID hysteresis loops showed a non‐negligible coer-cive field and remanence suggesting the ferromagnetic behavior of the particles. Heating efficiency measurements showed that both samples display high heating potentials and reached magnetic hyperthermia (42 °C) in relatively short times with shorter time (~3 min) observed for γ‐Fe2O3 com-pared to γ‐Fe2O3‐TiO2. The specific absorption rate (SAR) values calculated for γ‐Fe2O3 (up to 90 W/g) are higher than that for γ‐Fe2O3‐TiO2 (~40 W/g), confirming better heating efficiency for γ‐Fe2O3 NPs. The intrinsic loss power (ILP) values of 1.57 nHm2/kg and 0.64 nHm2/kg obtained for both nanocomposites are in the range reported for commercial ferrofluids (0.2–3.1 nHm2/kg). Finally, the heating mechanism responsible for NP heat dissipation is explained concluding that both Neel and Brownian relaxations are contributing to heat production. Overall, the obtained high heating efficiencies suggest that the fabricated nanocomposites hold a great potential to be utilized in a wide spectrum of applications, particularly in magnetic photothermal hyperthermia treatments.
KW - Alternating magnetic field
KW - Heating efficiency
KW - Iron oxide nanoparticles
KW - Maghemite
KW - Magnetic hyperthermia
KW - Sol‐Gel synthesis
KW - TiO2
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U2 - 10.3390/ma14195691
DO - 10.3390/ma14195691
M3 - Article
C2 - 34640088
AN - SCOPUS:85116157982
SN - 1996-1944
VL - 14
JO - Materials
JF - Materials
IS - 19
M1 - 5691
ER -