Macular cysts in retinal dystrophy

Anuradha Ganesh, Eliza Stroh, George J. Manayath, Sana Al-Zuhaibi, Alex V. Levin

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: To describe the entity of macular cysts in retinal dystrophy, differentiate it from cystoid macular edema (CME), and review the role of carbonic anhydrase inhibitors in management. RECENT FINDINGS: Macular cysts in retinal dystrophy are seen in retinopathies caused by mutations in the NR2E3 gene, juvenile X-linked retinoschisis (XLRS), and some other retinal dystrophies. These must be distinguished from CME. Optical coherence tomography can clearly demonstrate intraretinal cysts which may not be clinically detectable. Intravenous fluorescein angiography (IVFA) does not show macular hyperfluorescence (i.e. leakage). Molecular genetic testing aids in the diagnosis and elucidation of pathophysiology. Carbonic anhydrase inhibitors may promote resolution of the cysts resulting in visual improvement. SUMMARY: Non-CME macular cysts in retinal dystrophies can be differentiated from CME by a combination of clinical examination, IVFA, and molecular genetic testing to identify causative phenotype. Carbonic anhydrase inhibitors may be effective in promoting resolution.

Original languageEnglish
Pages (from-to)332-339
Number of pages8
JournalCurrent Opinion in Ophthalmology
Volume22
Issue number5
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Retinal Dystrophies
Macular Edema
Cysts
Carbonic Anhydrase Inhibitors
Fluorescein Angiography
Genetic Testing
Molecular Biology
Retinoschisis
Optical Coherence Tomography
Phenotype
Mutation
Genes

Keywords

  • carbonic anhydrase inhibitors
  • fluorescein angiography
  • macular cyst
  • NR2E3 retinopathy
  • retinal dystrophy
  • X-linked retinoschisis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Macular cysts in retinal dystrophy. / Ganesh, Anuradha; Stroh, Eliza; Manayath, George J.; Al-Zuhaibi, Sana; Levin, Alex V.

In: Current Opinion in Ophthalmology, Vol. 22, No. 5, 09.2011, p. 332-339.

Research output: Contribution to journalArticle

Ganesh, Anuradha ; Stroh, Eliza ; Manayath, George J. ; Al-Zuhaibi, Sana ; Levin, Alex V. / Macular cysts in retinal dystrophy. In: Current Opinion in Ophthalmology. 2011 ; Vol. 22, No. 5. pp. 332-339.
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