Lymphocytic infundibulo-neurohypophysitis: An unusual cause of recurrent optic neuropathy in a child

Abdullah Al-Mujaini; Anuradha Ganesh; Sana Al-Zuhaibi; Humoud Al-Dhuhli; Ali Al-Mashani; Hunaina Al-Kindi; Ali Al-Memari; Amna Al-Futaisi; Abdullah Al-Asmi

doi:10.1016/j.jaapos.2008.11.003

Lymphocytic infundibulo-neurohypophysitis: An unusual cause of recurrent optic neuropathy in a child

Abdullah Al-Mujaini, Anuradha Ganesh^*, Sana Al-Zuhaibi, Humoud Al-Dhuhli, Ali Al-Mashani, Hunaina Al-Kindi, Ali Al-Memari, Amna Al-Futaisi, Abdullah Al-Asmi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Lymphocytic infundibulo-neurohypophysitis (LINH), a rare autoimmune disease, is distinct from lymphocytic hypophysitis and is characterized by lymphocytic and plasma cell infiltration of the posterior lobe of the pituitary and the pituitary stalk.¹ We report the case of a young boy who presented with recurrent, steroid-responsive optic nerve dysfunction and diabetes insipidus. T1-weighted magnetic resonance imaging scans of the brain showed an isointense soft tissue mass within the sella turcica and a thickened pituitary stalk. Tissue specimen resected at transsphenoidal surgery revealed chronic inflammation with infiltration of lymphocytes and no granulomatosis or necrosis, establishing the diagnosis of LINH.² This is the first report of optic neuropathy in association with LINH in a child.

Original language	English
Pages (from-to)	207-209
Number of pages	3
Journal	Journal of AAPOS
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/j.jaapos.2008.11.003
Publication status	Published - Apr 2009

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Ophthalmology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaapos.2008.11.003

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title = "Lymphocytic infundibulo-neurohypophysitis: An unusual cause of recurrent optic neuropathy in a child",

abstract = "Lymphocytic infundibulo-neurohypophysitis (LINH), a rare autoimmune disease, is distinct from lymphocytic hypophysitis and is characterized by lymphocytic and plasma cell infiltration of the posterior lobe of the pituitary and the pituitary stalk.1 We report the case of a young boy who presented with recurrent, steroid-responsive optic nerve dysfunction and diabetes insipidus. T1-weighted magnetic resonance imaging scans of the brain showed an isointense soft tissue mass within the sella turcica and a thickened pituitary stalk. Tissue specimen resected at transsphenoidal surgery revealed chronic inflammation with infiltration of lymphocytes and no granulomatosis or necrosis, establishing the diagnosis of LINH.2 This is the first report of optic neuropathy in association with LINH in a child.",

author = "Abdullah Al-Mujaini and Anuradha Ganesh and Sana Al-Zuhaibi and Humoud Al-Dhuhli and Ali Al-Mashani and Hunaina Al-Kindi and Ali Al-Memari and Amna Al-Futaisi and Abdullah Al-Asmi",

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AU - Al-Mujaini, Abdullah

AU - Ganesh, Anuradha

AU - Al-Zuhaibi, Sana

AU - Al-Dhuhli, Humoud

AU - Al-Mashani, Ali

AU - Al-Kindi, Hunaina

AU - Al-Memari, Ali

AU - Al-Futaisi, Amna

AU - Al-Asmi, Abdullah

PY - 2009/4

Y1 - 2009/4

N2 - Lymphocytic infundibulo-neurohypophysitis (LINH), a rare autoimmune disease, is distinct from lymphocytic hypophysitis and is characterized by lymphocytic and plasma cell infiltration of the posterior lobe of the pituitary and the pituitary stalk.1 We report the case of a young boy who presented with recurrent, steroid-responsive optic nerve dysfunction and diabetes insipidus. T1-weighted magnetic resonance imaging scans of the brain showed an isointense soft tissue mass within the sella turcica and a thickened pituitary stalk. Tissue specimen resected at transsphenoidal surgery revealed chronic inflammation with infiltration of lymphocytes and no granulomatosis or necrosis, establishing the diagnosis of LINH.2 This is the first report of optic neuropathy in association with LINH in a child.

AB - Lymphocytic infundibulo-neurohypophysitis (LINH), a rare autoimmune disease, is distinct from lymphocytic hypophysitis and is characterized by lymphocytic and plasma cell infiltration of the posterior lobe of the pituitary and the pituitary stalk.1 We report the case of a young boy who presented with recurrent, steroid-responsive optic nerve dysfunction and diabetes insipidus. T1-weighted magnetic resonance imaging scans of the brain showed an isointense soft tissue mass within the sella turcica and a thickened pituitary stalk. Tissue specimen resected at transsphenoidal surgery revealed chronic inflammation with infiltration of lymphocytes and no granulomatosis or necrosis, establishing the diagnosis of LINH.2 This is the first report of optic neuropathy in association with LINH in a child.

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Lymphocytic infundibulo-neurohypophysitis: An unusual cause of recurrent optic neuropathy in a child

Abstract

ASJC Scopus subject areas

UN SDGs

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