Lymphocytic infundibulo-neurohypophysitis

An unusual cause of recurrent optic neuropathy in a child

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Lymphocytic infundibulo-neurohypophysitis (LINH), a rare autoimmune disease, is distinct from lymphocytic hypophysitis and is characterized by lymphocytic and plasma cell infiltration of the posterior lobe of the pituitary and the pituitary stalk.1 We report the case of a young boy who presented with recurrent, steroid-responsive optic nerve dysfunction and diabetes insipidus. T1-weighted magnetic resonance imaging scans of the brain showed an isointense soft tissue mass within the sella turcica and a thickened pituitary stalk. Tissue specimen resected at transsphenoidal surgery revealed chronic inflammation with infiltration of lymphocytes and no granulomatosis or necrosis, establishing the diagnosis of LINH.2 This is the first report of optic neuropathy in association with LINH in a child.

Original languageEnglish
Pages (from-to)207-209
Number of pages3
JournalJournal of AAPOS
Volume13
Issue number2
DOIs
Publication statusPublished - Apr 2009

Fingerprint

Optic Nerve Diseases
Sella Turcica
Posterior Pituitary Gland
Diabetes Insipidus
Pituitary Gland
Optic Nerve
Rare Diseases
Plasma Cells
Autoimmune Diseases
Necrosis
Steroids
Magnetic Resonance Imaging
Lymphocytes
Inflammation
Brain
Autoimmune Hypophysitis

ASJC Scopus subject areas

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Lymphocytic infundibulo-neurohypophysitis: An unusual cause of recurrent optic neuropathy in a child",
abstract = "Lymphocytic infundibulo-neurohypophysitis (LINH), a rare autoimmune disease, is distinct from lymphocytic hypophysitis and is characterized by lymphocytic and plasma cell infiltration of the posterior lobe of the pituitary and the pituitary stalk.1 We report the case of a young boy who presented with recurrent, steroid-responsive optic nerve dysfunction and diabetes insipidus. T1-weighted magnetic resonance imaging scans of the brain showed an isointense soft tissue mass within the sella turcica and a thickened pituitary stalk. Tissue specimen resected at transsphenoidal surgery revealed chronic inflammation with infiltration of lymphocytes and no granulomatosis or necrosis, establishing the diagnosis of LINH.2 This is the first report of optic neuropathy in association with LINH in a child.",
author = "Abdullah Al-Mujaini and Anuradha Ganesh and Sana Al-Zuhaibi and Humoud Al-Dhuhli and Ali Al-Mashani and Hunaina Al-Kindi and Ali Al-Memari and Amna Al-Futaisi and Abdullah Al-Asmi",
year = "2009",
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T1 - Lymphocytic infundibulo-neurohypophysitis

T2 - An unusual cause of recurrent optic neuropathy in a child

AU - Al-Mujaini, Abdullah

AU - Ganesh, Anuradha

AU - Al-Zuhaibi, Sana

AU - Al-Dhuhli, Humoud

AU - Al-Mashani, Ali

AU - Al-Kindi, Hunaina

AU - Al-Memari, Ali

AU - Al-Futaisi, Amna

AU - Al-Asmi, Abdullah

PY - 2009/4

Y1 - 2009/4

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AB - Lymphocytic infundibulo-neurohypophysitis (LINH), a rare autoimmune disease, is distinct from lymphocytic hypophysitis and is characterized by lymphocytic and plasma cell infiltration of the posterior lobe of the pituitary and the pituitary stalk.1 We report the case of a young boy who presented with recurrent, steroid-responsive optic nerve dysfunction and diabetes insipidus. T1-weighted magnetic resonance imaging scans of the brain showed an isointense soft tissue mass within the sella turcica and a thickened pituitary stalk. Tissue specimen resected at transsphenoidal surgery revealed chronic inflammation with infiltration of lymphocytes and no granulomatosis or necrosis, establishing the diagnosis of LINH.2 This is the first report of optic neuropathy in association with LINH in a child.

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