Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection

Julien van Grevenynghe, Rabih Halwani, Nicolas Chomont, Petronela Ancuta, Yoav Peretz, Andre Tanel, Francesco A. Procopio, Yu shi, Elias A. Said, Elias K. Haddad, Rafick P. Sekaly*

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Lymph nodes (LNs) represent the principal site where antigen-specific memory T- and B-cell responses are primed and differentiated into memory and effector cells. During chronic viral infections such as HIV, these lymphoid tissues undergo substantial structural changes. These changes are mostly caused by an imbalanced cytokine milieu, hyper-immune activation and collagen deposition leading to fibrotic LNs. The structural integrity of the LNs is essential to prime and maintain memory responses. Because cellular signalling events both up- and down-stream of FOXO3a are critical to the generation and the maintenance of lymphocyte memory, this review will focus on the interplay between the deregulation of the immune system caused by the virus and its impact on FOXO3a.

Original languageEnglish
Pages (from-to)196-203
Number of pages8
JournalSeminars in Immunology
Volume20
Issue number3
DOIs
Publication statusPublished - Jun 2008

Keywords

  • FOXO3a pathways
  • HIV infection
  • Lymph nodes architecture
  • Memory B cell
  • Memory T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

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