Long-term effects of interference on short-term memory performance in the rat

Mégane Missaire, Nicolas Fraize, Mickaël Antoine Joseph, Al Mahdy Hamieh, Régis Parmentier, Aline Marighetto, Paul Antoine Salin, Gaël Malleret

Research output: Contribution to journalArticle

Abstract

A distinction has always been made between long-term and short-term memory (also now called working memory, WM). The obvious difference between these two kinds of memory concerns the duration of information storage: information is supposedly transiently stored in WM while it is considered durably consolidated into long-term memory. It is well acknowledged that the content of WM is erased and reset after a short time, to prevent irrelevant information from proactively interfering with newly stored information. In the present study, we used typical WM radial maze tasks to question the brief lifespan of spatial WM content in rodents. Groups of rats were submitted to one of two different WM tasks in a radial maze: a WM task involving the repetitive presentation of a same pair of arms expected to induce a high level of proactive interference (PI) (HIWM task), or a task using a different pair in each trial expected to induce a low level of PI (LIWM task). Performance was effectively lower in the HIWM group than in LIWM in the final trial of each training session, indicative of a "within-session/short-term" PI effect. However, we also observed a different "between-session/long-term" PI effect between the two groups: while performance of LIWM trained rats remained stable over days, the performance of HIWM rats dropped after 10 days of training, and this impairment was visible from the very first trial of the day, hence not attributable to within-session PI. We also showed that a 24 hour-gap across training sessions known to allow consolidation processes to unfold, was a necessary and sufficient condition for the long-term PI effect to occur. These findings suggest that in the HIWM task, WM content was not entirely reset between training sessions and that, in specific conditions, WM content can outlast its purpose by being stored more permanently, generating a long-term deleterious effect of PI. The alternative explanation is that WM content could be transferred and stored more permanently in an intermediary form or memory between WM and long-term memory.

Original languageEnglish
Article numbere0173834
JournalPLoS One
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 1 2017

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Short-Term Memory
long term effects
Rats
Data storage equipment
rats
Long-Term Memory
Information Storage and Retrieval
Rodentia
working conditions
Consolidation
rodents

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Missaire, M., Fraize, N., Joseph, M. A., Hamieh, A. M., Parmentier, R., Marighetto, A., ... Malleret, G. (2017). Long-term effects of interference on short-term memory performance in the rat. PLoS One, 12(3), [e0173834]. https://doi.org/10.1371/journal.pone.0173834

Long-term effects of interference on short-term memory performance in the rat. / Missaire, Mégane; Fraize, Nicolas; Joseph, Mickaël Antoine; Hamieh, Al Mahdy; Parmentier, Régis; Marighetto, Aline; Salin, Paul Antoine; Malleret, Gaël.

In: PLoS One, Vol. 12, No. 3, e0173834, 01.03.2017.

Research output: Contribution to journalArticle

Missaire, M, Fraize, N, Joseph, MA, Hamieh, AM, Parmentier, R, Marighetto, A, Salin, PA & Malleret, G 2017, 'Long-term effects of interference on short-term memory performance in the rat', PLoS One, vol. 12, no. 3, e0173834. https://doi.org/10.1371/journal.pone.0173834
Missaire M, Fraize N, Joseph MA, Hamieh AM, Parmentier R, Marighetto A et al. Long-term effects of interference on short-term memory performance in the rat. PLoS One. 2017 Mar 1;12(3). e0173834. https://doi.org/10.1371/journal.pone.0173834
Missaire, Mégane ; Fraize, Nicolas ; Joseph, Mickaël Antoine ; Hamieh, Al Mahdy ; Parmentier, Régis ; Marighetto, Aline ; Salin, Paul Antoine ; Malleret, Gaël. / Long-term effects of interference on short-term memory performance in the rat. In: PLoS One. 2017 ; Vol. 12, No. 3.
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