Long-Term dietary supplementation of pomegranates, figs and dates alleviate neuroinflammation in a transgenic mouse model of alzheimer's disease

Musthafa Mohamed Essa, Selvaraju Subash, Mohammed Akbar, Samir Al-Adawi, Gilles J. Guillemin

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease with no specific treatment at present. The APPsw/Tg2576 mice exhibit age-related deterioration in memory and learning as well as amyloid-beta (Aβ) accumulation, and this mouse strain is considered an effective model for studying the mechanism of accelerated brain aging and senescence. The present study was aimed to investigate the beneficial effects of dietary supplements pomegranate, figs, or the dates on suppressing inflammatory cytokines in APPsw/Tg2576 mice. Changes in the plasma cytokines and Aβ, ATP, and inflammatory cytokines were investigated in the brain of transgenic mice. Significantly enhanced levels of inflammatory cytokines IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-9, IL-10, TNF-α and Eotaxin activity were decreased by administration of the diet supplements containing pomegranates, figs, or dates. In addition, putative delays in the formation of senile plaques, as indicated by a decreasing tendency of brain Aβ1-40 and Aβ1-42 contents, were observed. Thus, novel results mediated by reducing inflammatory cytokines during aging may represent one mechanism by which these supplements exert their beneficial effects against neurodegenerative diseases such as AD.

Original languageEnglish
Article numbere0120964
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 25 2015

Fingerprint

pomegranates
Ficus
figs
Alzheimer disease
Dietary Supplements
Transgenic Mice
dietary supplements
Alzheimer Disease
cytokines
animal models
genetically modified organisms
Cytokines
Neurodegenerative diseases
Brain
mice
neurodegenerative diseases
brain
Neurodegenerative Diseases
interleukin-9
Dietary supplements

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Long-Term dietary supplementation of pomegranates, figs and dates alleviate neuroinflammation in a transgenic mouse model of alzheimer's disease. / Essa, Musthafa Mohamed; Subash, Selvaraju; Akbar, Mohammed; Al-Adawi, Samir; Guillemin, Gilles J.

In: PLoS One, Vol. 10, No. 3, e0120964, 25.03.2015.

Research output: Contribution to journalArticle

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