Loci impacting polymorphic gait in the Tennessee Walking Horse

E. A. Staiger, M. A. Abri, C. A.S. Silva, S. A. Brooks

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Following domestication, man selected the horse primarily for the purpose of transportation rather than consumption; this selective strategy created divergent traits for locomotion. At intermediate speeds, beyond the flat walk, the horse can perform a range of diagonal and lateral 2-beat or 4-beat gait patterns. The Tennessee Walking Horse (TWH) is the only U.S. breed able to perform an even-timed 4-beat gait (the “running-walk”) at intermediate speeds; however, within the breed, there is remaining variation in gait type. To investigate the contribution of genetics to this unique trait, blood or hair samples for DNA and gait information were collected from 129 TWH and genotyping was performed at approximately 60,000 loci using the Illumina Equine SNP70 beadchip at GeneSeek Inc. (Lincoln, NE). Case–control association tests identified suggestive regions for gait type on equine chromosome (ECA) 19 (P-value of 1.50 × 10–5 after 1 million permutations; PLINK version 1.07). Haplotype analysis identified 2 significant haplotypes on ECA19 and ECA11 (P-values of 3.7 × 10–5 and 3.92 × 10–5, respectively). Genes within these suggestive regions play roles in developmental processes and biological regulation, indicating there may be variant differences in the neurobiology and regulation of horses with a polymorphic gait.

Original languageEnglish
Pages (from-to)1377-1386
Number of pages10
JournalJournal of Animal Science
Volume94
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

gait
Gait
Horses
Walking
loci
horses
haplotypes
Haplotypes
breeds
neurophysiology
Chromosomes, Human, Pair 19
Biological Phenomena
domestication
Neurobiology
genotyping
Locomotion
hairs
locomotion
Tennessee Walking Horse
Running

Keywords

  • Gait
  • Genome-wide association study
  • Horse
  • Running walk

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

Cite this

Loci impacting polymorphic gait in the Tennessee Walking Horse. / Staiger, E. A.; Abri, M. A.; Silva, C. A.S.; Brooks, S. A.

In: Journal of Animal Science, Vol. 94, No. 4, 01.04.2016, p. 1377-1386.

Research output: Contribution to journalArticle

Staiger, E. A. ; Abri, M. A. ; Silva, C. A.S. ; Brooks, S. A. / Loci impacting polymorphic gait in the Tennessee Walking Horse. In: Journal of Animal Science. 2016 ; Vol. 94, No. 4. pp. 1377-1386.
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