Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats

A. A. Al-Qarawi, H. A. Abdel-Rahman, B. H. Ali, S. A. El Mougy

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The effect of oral administration of a water freeze-dried extract of Glycyrrhiza glabra (liquorice) has been studied at doses of 100, 250 and 500 mg/kg in rats on the plasma concentration of cortisol, adrenocorticotrophic hormone (ACTH), aldosterone, renin, sodium (Na) and potassium (K). The results indicated that treatment induced dose-dependent and mostly significant decreases in the concentration of cortisol, ACTH, aldosterone and K. There were concomitant dose-dependent increases in the concentrations of renin and Na. The results suggest a strong and dose-dependent suppression of the adrenal-pituitary axis, accompanied by stimulation of renin production from the kidney.

Original languageEnglish
Pages (from-to)1525-1527
Number of pages3
JournalFood and Chemical Toxicology
Volume40
Issue number10
DOIs
Publication statusPublished - Oct 2002

Fingerprint

Glycyrrhiza glabra
Glycyrrhiza
licorice
Renin
renin
Rats
kidneys
Aldosterone
Kidney
Adrenocorticotropic Hormone
aldosterone
Hydrocortisone
rats
corticotropin
dosage
cortisol
Oral Administration
Potassium
Sodium
oral administration

Keywords

  • Adrenal gland
  • Aldosterone
  • Liquorice
  • Pituitary
  • Rats

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats. / Al-Qarawi, A. A.; Abdel-Rahman, H. A.; Ali, B. H.; El Mougy, S. A.

In: Food and Chemical Toxicology, Vol. 40, No. 10, 10.2002, p. 1525-1527.

Research output: Contribution to journalArticle

Al-Qarawi, A. A. ; Abdel-Rahman, H. A. ; Ali, B. H. ; El Mougy, S. A. / Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats. In: Food and Chemical Toxicology. 2002 ; Vol. 40, No. 10. pp. 1525-1527.
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