Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against: Staphylococcus aureus

Georgina C. Girt, Amit Mahindra, Zaaima J.H. Al Jabri, Megan De Ste Croix, Marco R. Oggioni, Andrew G. Jamieson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

Original languageEnglish
Pages (from-to)2767-2770
Number of pages4
JournalChemical Communications
Volume54
Issue number22
DOIs
Publication statusPublished - Jan 1 2018

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Anchors
Substitution reactions
Membranes
Costs
L-allo-enduracididine
teixobactin

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against : Staphylococcus aureus. / Girt, Georgina C.; Mahindra, Amit; Al Jabri, Zaaima J.H.; De Ste Croix, Megan; Oggioni, Marco R.; Jamieson, Andrew G.

In: Chemical Communications, Vol. 54, No. 22, 01.01.2018, p. 2767-2770.

Research output: Contribution to journalArticle

Girt, Georgina C. ; Mahindra, Amit ; Al Jabri, Zaaima J.H. ; De Ste Croix, Megan ; Oggioni, Marco R. ; Jamieson, Andrew G. / Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against : Staphylococcus aureus. In: Chemical Communications. 2018 ; Vol. 54, No. 22. pp. 2767-2770.
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