Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against

Staphylococcus aureus

Georgina C. Girt, Amit Mahindra, Zaaima J.H. Al Jabri, Megan De Ste Croix, Marco R. Oggioni, Andrew G. Jamieson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

Original languageEnglish
Pages (from-to)2767-2770
Number of pages4
JournalChemical Communications
Volume54
Issue number22
DOIs
Publication statusPublished - Jan 1 2018

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Anchors
Substitution reactions
Membranes
Costs
L-allo-enduracididine
teixobactin

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against : Staphylococcus aureus. / Girt, Georgina C.; Mahindra, Amit; Al Jabri, Zaaima J.H.; De Ste Croix, Megan; Oggioni, Marco R.; Jamieson, Andrew G.

In: Chemical Communications, Vol. 54, No. 22, 01.01.2018, p. 2767-2770.

Research output: Contribution to journalArticle

Girt, Georgina C. ; Mahindra, Amit ; Al Jabri, Zaaima J.H. ; De Ste Croix, Megan ; Oggioni, Marco R. ; Jamieson, Andrew G. / Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against : Staphylococcus aureus. In: Chemical Communications. 2018 ; Vol. 54, No. 22. pp. 2767-2770.
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