Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against: Staphylococcus aureus

Georgina C. Girt, Amit Mahindra, Zaaima J.H. Al Jabri, Megan De Ste Croix, Marco R. Oggioni, Andrew G. Jamieson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

Original languageEnglish
Pages (from-to)2767-2770
Number of pages4
JournalChemical Communications
Volume54
Issue number22
DOIs
Publication statusPublished - Jan 1 2018

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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