Levels of interference in long and short-term memory differentially modulate Non-REM and REM Sleep

Nicolas Fraize, Julien Carponcy, Mickaël Antoine Joseph, Jean Christophe Comte, Pierre Hervé Luppi, Paul Antoine Libourel, Paul Antoine Salin, Gaël Malleret, Régis Parmentier

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Study Objectives: It is commonly accepted that sleep is beneficial to memory processes, but it is still unclear if this benefit originates from improved memory consolidation or enhanced information processing. It has thus been proposed that sleep may also promote forgetting of undesirable and non-essential memories, a process required for optimization of cognitive resources. We tested the hypothesis that non-rapid eye movement sleep (NREMS) promotes forgetting of irrelevant information, more specifically when processing information in working memory (WM), while REM sleep (REMS) facilitates the consolidation of important information. Methods: We recorded sleep patterns of rats trained in a radial maze in three different tasks engaging either the long-term or short-term storage of information, as well as a gradual level of interference. Results: We observed a transient increase in REMS amount on the day the animal learned the rule of a long-term/reference memory task (RM), and, in contrast, a positive correlation between the performance of rats trained in a WM task involving an important processing of interference and the amount of NREMS or slow wave activity. Various oscillatory events were also differentially modulated by the type of training involved. Notably, NREMS spindles and REMS rapid theta increase with RM training, while sharp-wave ripples increase with all types of training. Conclusions: These results suggest that REMS, but also rapid oscillations occurring during NREMS would be specifically implicated in the long-term memory in RM, whereas NREMS and slow oscillations could be involved in the forgetting of irrelevant information required for WM.

Original languageEnglish
Pages (from-to)2173-2188
Number of pages16
JournalSleep
Volume39
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Long-Term Memory
REM Sleep
Short-Term Memory
Sleep
Eye Movements
Automatic Data Processing
Information Storage and Retrieval
Learning

Keywords

  • Forgetting
  • Interference
  • Oscillations
  • Reference memory
  • REM sleep
  • Sleep
  • Slow-wave sleep
  • Working memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)

Cite this

Fraize, N., Carponcy, J., Joseph, M. A., Comte, J. C., Luppi, P. H., Libourel, P. A., ... Parmentier, R. (2016). Levels of interference in long and short-term memory differentially modulate Non-REM and REM Sleep. Sleep, 39(12), 2173-2188. https://doi.org/10.5665/sleep.6322

Levels of interference in long and short-term memory differentially modulate Non-REM and REM Sleep. / Fraize, Nicolas; Carponcy, Julien; Joseph, Mickaël Antoine; Comte, Jean Christophe; Luppi, Pierre Hervé; Libourel, Paul Antoine; Salin, Paul Antoine; Malleret, Gaël; Parmentier, Régis.

In: Sleep, Vol. 39, No. 12, 01.12.2016, p. 2173-2188.

Research output: Contribution to journalArticle

Fraize, N, Carponcy, J, Joseph, MA, Comte, JC, Luppi, PH, Libourel, PA, Salin, PA, Malleret, G & Parmentier, R 2016, 'Levels of interference in long and short-term memory differentially modulate Non-REM and REM Sleep', Sleep, vol. 39, no. 12, pp. 2173-2188. https://doi.org/10.5665/sleep.6322
Fraize, Nicolas ; Carponcy, Julien ; Joseph, Mickaël Antoine ; Comte, Jean Christophe ; Luppi, Pierre Hervé ; Libourel, Paul Antoine ; Salin, Paul Antoine ; Malleret, Gaël ; Parmentier, Régis. / Levels of interference in long and short-term memory differentially modulate Non-REM and REM Sleep. In: Sleep. 2016 ; Vol. 39, No. 12. pp. 2173-2188.
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