Leptinemia among obese Omani adults newly diagnosed with type 2 diabetes mellitus: A case-control study

Mostafa I. Waly, Amanat Ali*, Yahya M. Al-Farsi, Neeru Bhatt, Hashim Al-Kilani, Allal Ouhtit, Masoud Y. Al-Maskari

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Leptinemia is associated with obesity and obesity and hyperinsulinemia are considered as the main etiological factors for type 2 diabetes mellitus (T2DM) among adult subjects. The present case-control study evaluated the dietaiy pattern and biochemical profile of newly diagnosed T2DM obese Omani adults as compared to their age, weight and gender matched control subjects. Two hundred Omani adults (100 obese adults newly diagnosed with T2DM and 100 healthy controls) were included in this study. Dietaiy intake, body mass index and biochemical measurements for fasting serum glucose, insulin, leptin and blood glycated hemoglobin levels were evaluated for all study participants. Subjects with T2DM showed significantly (p<0.05) higher daily intake of total fats, carbohydrates and energy as compared to controls. Leptinemia and hyperinsulinemia were common among obese diabetic adults as compared to controls. The mean fasting serum levels of glucose and glycated hemoglobin in obese diabetic subjects were significantly (p<0.05) higher than controls. Serum leptin level was found to be positively correlated with body mass index, serum insulin level and total energy intake in all the study subjects. Our results suggest that leptinemia is a risk factor for T2DM in obese Omani adults.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalJournal of Medical Sciences (Faisalabad)
Volume13
Issue number3
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Dietaiy pattern
  • Leptin
  • Obesity
  • Omani adults
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Medicine(all)

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