Leishmania infantum and Epstein-Barr virus co-infection in a patient with hemophagocytosis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The authors describe a rare case of a 27- year old previously healthy male presenting with high grade fever, pancytopenia, hepatosplenomegaly, high levels of ferritin and triglyceride, suggesting a diagnosis of hemophagocytic lymphohistiocytosis (HLH) syndrome. Other investigations showed a positive Leishmania infantum serology and high Epstein-Barr virus (EBV) viremia. The diagnosis of a visceral leishmaniasis was confirmed by bone morrow biopsy, which showed Leishman-Donovan bodies and evidence of HLH. The patient received liposomal amphotericin B and he had a complete resolution of his symptoms and clearance of EBV viremia. This case of HLH associated with visceral leishmaniasis and EBV co-infection raises the question about the significance of EBV in patients with HLH. The treatment of actual etiological agent can lead to complete cure while using current recommend chemotherapy for HLH-related EBV in a patient with hidden infection may have deleterious effects.

Original languageEnglish
Pages (from-to)78-79
Number of pages2
JournalInfectious Disease Reports
Volume8
Issue number4
DOIs
Publication statusPublished - 2016

Fingerprint

Leishmania infantum
Hemophagocytic Lymphohistiocytosis
Epstein-Barr Virus Infections
Coinfection
Human Herpesvirus 4
Visceral Leishmaniasis
Viremia
Pancytopenia
Serology
Ferritins
Triglycerides
Fever
Biopsy
Bone and Bones
Drug Therapy
Infection

Keywords

  • Coinfection
  • Epstein-Barr virus
  • Hemophagocytosis
  • Leishmania infantum

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Leishmania infantum and Epstein-Barr virus co-infection in a patient with hemophagocytosis. / Gaifer, Zied; Boulassel, Mohamed Rachid.

In: Infectious Disease Reports, Vol. 8, No. 4, 2016, p. 78-79.

Research output: Contribution to journalArticle

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