Lack of Increased P15ink4b protein Expression in Basal Cell Carcinomas

Ahmed Ismail Hassan Moad, Mei Lan Tan, Gurjeet Kaur, Mohamed Mabruk

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The basal cell carcinoma (BCC) is the most common non-melanoma skin cancer (NMSK). BCC might develop because of the faulty cell cycle arrest. P15INK4b is a tumor suppressor gene, involved in cell cycle arrest and inactivated in most human cancers. The role of p15INK4b protein expression in the genesis of BCC is as yet unknown. In a previous study we showed the absence of p15INK4b expression in the majority of tissue microarray cores of cutaneous squamous cell carcinoma (SCCs), another type of non-melanoma skin cancer, indicating that p15INK4b could possibly be involved in the pathogenesis of cutaneous SCC. The aim of this study was to investigate p15INK4b protein expression in BCCs. Materials and Method: Protein expression of p15INK4b in 35 cases of BCC tissue arrays and 19 cases of normal human skin tissue was studied using an immunohistochemical approach. Results: The expression of p15INK4b was not significantly different in the BCC cases as compared with normal human skin (p=0.356; p>0.05). In addition, there were no significant relationship between clinicopathologic variables of patients (age and sex) and p15INK4b protein expression. Conclusions: Our finding may indicate that p15INK4b protein expression does not play a role in the genesis of BCC.

Original languageEnglish
Pages (from-to)6239-6244
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume13
Issue number12
DOIs
Publication statusPublished - 2012

Fingerprint

Cyclin-Dependent Kinase Inhibitor p15
Basal Cell Carcinoma
Skin
Skin Neoplasms
Cell Cycle Checkpoints
Squamous Cell Carcinoma
Tumor Suppressor Genes

Keywords

  • Basal cell carcinoma
  • Immunohistichemistry
  • P15Ink4B

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Lack of Increased P15ink4b protein Expression in Basal Cell Carcinomas. / Moad, Ahmed Ismail Hassan; Tan, Mei Lan; Kaur, Gurjeet; Mabruk, Mohamed.

In: Asian Pacific Journal of Cancer Prevention, Vol. 13, No. 12, 2012, p. 6239-6244.

Research output: Contribution to journalArticle

Moad, Ahmed Ismail Hassan ; Tan, Mei Lan ; Kaur, Gurjeet ; Mabruk, Mohamed. / Lack of Increased P15ink4b protein Expression in Basal Cell Carcinomas. In: Asian Pacific Journal of Cancer Prevention. 2012 ; Vol. 13, No. 12. pp. 6239-6244.
@article{4632008ca17746268ef0c712068202f5,
title = "Lack of Increased P15ink4b protein Expression in Basal Cell Carcinomas",
abstract = "Background: The basal cell carcinoma (BCC) is the most common non-melanoma skin cancer (NMSK). BCC might develop because of the faulty cell cycle arrest. P15INK4b is a tumor suppressor gene, involved in cell cycle arrest and inactivated in most human cancers. The role of p15INK4b protein expression in the genesis of BCC is as yet unknown. In a previous study we showed the absence of p15INK4b expression in the majority of tissue microarray cores of cutaneous squamous cell carcinoma (SCCs), another type of non-melanoma skin cancer, indicating that p15INK4b could possibly be involved in the pathogenesis of cutaneous SCC. The aim of this study was to investigate p15INK4b protein expression in BCCs. Materials and Method: Protein expression of p15INK4b in 35 cases of BCC tissue arrays and 19 cases of normal human skin tissue was studied using an immunohistochemical approach. Results: The expression of p15INK4b was not significantly different in the BCC cases as compared with normal human skin (p=0.356; p>0.05). In addition, there were no significant relationship between clinicopathologic variables of patients (age and sex) and p15INK4b protein expression. Conclusions: Our finding may indicate that p15INK4b protein expression does not play a role in the genesis of BCC.",
keywords = "Basal cell carcinoma, Immunohistichemistry, P15Ink4B",
author = "Moad, {Ahmed Ismail Hassan} and Tan, {Mei Lan} and Gurjeet Kaur and Mohamed Mabruk",
year = "2012",
doi = "10.7314/APJCP.2012.13.12.6239",
language = "English",
volume = "13",
pages = "6239--6244",
journal = "Asian Pacific Journal of Cancer Prevention",
issn = "1513-7368",
publisher = "Asian Pacific Organization for Cancer Prevention",
number = "12",

}

TY - JOUR

T1 - Lack of Increased P15ink4b protein Expression in Basal Cell Carcinomas

AU - Moad, Ahmed Ismail Hassan

AU - Tan, Mei Lan

AU - Kaur, Gurjeet

AU - Mabruk, Mohamed

PY - 2012

Y1 - 2012

N2 - Background: The basal cell carcinoma (BCC) is the most common non-melanoma skin cancer (NMSK). BCC might develop because of the faulty cell cycle arrest. P15INK4b is a tumor suppressor gene, involved in cell cycle arrest and inactivated in most human cancers. The role of p15INK4b protein expression in the genesis of BCC is as yet unknown. In a previous study we showed the absence of p15INK4b expression in the majority of tissue microarray cores of cutaneous squamous cell carcinoma (SCCs), another type of non-melanoma skin cancer, indicating that p15INK4b could possibly be involved in the pathogenesis of cutaneous SCC. The aim of this study was to investigate p15INK4b protein expression in BCCs. Materials and Method: Protein expression of p15INK4b in 35 cases of BCC tissue arrays and 19 cases of normal human skin tissue was studied using an immunohistochemical approach. Results: The expression of p15INK4b was not significantly different in the BCC cases as compared with normal human skin (p=0.356; p>0.05). In addition, there were no significant relationship between clinicopathologic variables of patients (age and sex) and p15INK4b protein expression. Conclusions: Our finding may indicate that p15INK4b protein expression does not play a role in the genesis of BCC.

AB - Background: The basal cell carcinoma (BCC) is the most common non-melanoma skin cancer (NMSK). BCC might develop because of the faulty cell cycle arrest. P15INK4b is a tumor suppressor gene, involved in cell cycle arrest and inactivated in most human cancers. The role of p15INK4b protein expression in the genesis of BCC is as yet unknown. In a previous study we showed the absence of p15INK4b expression in the majority of tissue microarray cores of cutaneous squamous cell carcinoma (SCCs), another type of non-melanoma skin cancer, indicating that p15INK4b could possibly be involved in the pathogenesis of cutaneous SCC. The aim of this study was to investigate p15INK4b protein expression in BCCs. Materials and Method: Protein expression of p15INK4b in 35 cases of BCC tissue arrays and 19 cases of normal human skin tissue was studied using an immunohistochemical approach. Results: The expression of p15INK4b was not significantly different in the BCC cases as compared with normal human skin (p=0.356; p>0.05). In addition, there were no significant relationship between clinicopathologic variables of patients (age and sex) and p15INK4b protein expression. Conclusions: Our finding may indicate that p15INK4b protein expression does not play a role in the genesis of BCC.

KW - Basal cell carcinoma

KW - Immunohistichemistry

KW - P15Ink4B

UR - http://www.scopus.com/inward/record.url?scp=84877062737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877062737&partnerID=8YFLogxK

U2 - 10.7314/APJCP.2012.13.12.6239

DO - 10.7314/APJCP.2012.13.12.6239

M3 - Article

C2 - 23464438

AN - SCOPUS:84877062737

VL - 13

SP - 6239

EP - 6244

JO - Asian Pacific Journal of Cancer Prevention

JF - Asian Pacific Journal of Cancer Prevention

SN - 1513-7368

IS - 12

ER -