Abstract
The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA- rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre- treatment prevented cocaine-induced ischemic changes, especially in these DA- rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.
| Original language | English |
|---|---|
| Pages (from-to) | 335-341 |
| Number of pages | 7 |
| Journal | Psychopharmacology |
| Volume | 136 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1998 |
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Keywords
- Brain blood flow
- Calcium channel antagonist
- Cocaine
- Human
- Ischemia
- Isradipine
- Quantitative SPECT
- Stroke
ASJC Scopus subject areas
- Pharmacology
Cite this
Isradipine prevents global and regional cocaine-induced changes in brain blood flow : A preliminary study. / Johnson, Bankole; Barron, Bruce; Fang, Bing; Lamki, Lamk; Wagner, Louis; Wells, Lynda; Kenny, Paul; Overton, Dennis; Dhother, Sukhindar; Abramson, David; Chen, Richard; Kramer, Larry.
In: Psychopharmacology, Vol. 136, No. 4, 1998, p. 335-341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isradipine prevents global and regional cocaine-induced changes in brain blood flow
T2 - A preliminary study
AU - Johnson, Bankole
AU - Barron, Bruce
AU - Fang, Bing
AU - Lamki, Lamk
AU - Wagner, Louis
AU - Wells, Lynda
AU - Kenny, Paul
AU - Overton, Dennis
AU - Dhother, Sukhindar
AU - Abramson, David
AU - Chen, Richard
AU - Kramer, Larry
PY - 1998
Y1 - 1998
N2 - The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA- rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre- treatment prevented cocaine-induced ischemic changes, especially in these DA- rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.
AB - The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA- rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre- treatment prevented cocaine-induced ischemic changes, especially in these DA- rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.
KW - Brain blood flow
KW - Calcium channel antagonist
KW - Cocaine
KW - Human
KW - Ischemia
KW - Isradipine
KW - Quantitative SPECT
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=7144264387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7144264387&partnerID=8YFLogxK
U2 - 10.1007/s002130050575
DO - 10.1007/s002130050575
M3 - Article
C2 - 9600578
AN - SCOPUS:7144264387
VL - 136
SP - 335
EP - 341
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 4
ER -