Isradipine prevents global and regional cocaine-induced changes in brain blood flow: A preliminary study

Bankole Johnson; Bruce Barron; Bing Fang; Lamk Lamki; Louis Wagner; Lynda Wells; Paul Kenny; Dennis Overton; Sukhindar Dhother; David Abramson; Richard Chen; Larry Kramer

doi:10.1007/s002130050575

Isradipine prevents global and regional cocaine-induced changes in brain blood flow: A preliminary study

Bankole Johnson^*, Bruce Barron, Bing Fang, Lamk Lamki, Louis Wagner, Lynda Wells, Paul Kenny, Dennis Overton, Sukhindar Dhother, David Abramson, Richard Chen, Larry Kramer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA- rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre- treatment prevented cocaine-induced ischemic changes, especially in these DA- rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.

Original language	English
Pages (from-to)	335-341
Number of pages	7
Journal	Psychopharmacology
Volume	136
Issue number	4
DOIs	https://doi.org/10.1007/s002130050575
Publication status	Published - 1998
Externally published	Yes

Keywords

Brain blood flow
Calcium channel antagonist
Cocaine
Human
Ischemia
Isradipine
Quantitative SPECT
Stroke

ASJC Scopus subject areas

Pharmacology

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10.1007/s002130050575

Cite this

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title = "Isradipine prevents global and regional cocaine-induced changes in brain blood flow: A preliminary study",

abstract = "The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA- rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre- treatment prevented cocaine-induced ischemic changes, especially in these DA- rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.",

keywords = "Brain blood flow, Calcium channel antagonist, Cocaine, Human, Ischemia, Isradipine, Quantitative SPECT, Stroke",

author = "Bankole Johnson and Bruce Barron and Bing Fang and Lamk Lamki and Louis Wagner and Lynda Wells and Paul Kenny and Dennis Overton and Sukhindar Dhother and David Abramson and Richard Chen and Larry Kramer",

note = "Funding Information: Acknowledgements We would like to thank the sta⁄ at CLEAR, UCRC, and the Departments of Nuclear Medicine, and Anesthesiology for assistance. We are grateful for funding of this project by the Advanced Technology Program of Texas # 011618–006 and NIH grant # M01RR02558. Tc-ECD was kindly supplied by Du Pont Pharma.",

year = "1998",

doi = "10.1007/s002130050575",

language = "English",

volume = "136",

pages = "335--341",

journal = "Psychopharmacology",

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T1 - Isradipine prevents global and regional cocaine-induced changes in brain blood flow

T2 - A preliminary study

AU - Johnson, Bankole

AU - Barron, Bruce

AU - Fang, Bing

AU - Lamki, Lamk

AU - Wagner, Louis

AU - Wells, Lynda

AU - Kenny, Paul

AU - Overton, Dennis

AU - Dhother, Sukhindar

AU - Abramson, David

AU - Chen, Richard

AU - Kramer, Larry

N1 - Funding Information: Acknowledgements We would like to thank the sta⁄ at CLEAR, UCRC, and the Departments of Nuclear Medicine, and Anesthesiology for assistance. We are grateful for funding of this project by the Advanced Technology Program of Texas # 011618–006 and NIH grant # M01RR02558. Tc-ECD was kindly supplied by Du Pont Pharma.

PY - 1998

Y1 - 1998

N2 - The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA- rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre- treatment prevented cocaine-induced ischemic changes, especially in these DA- rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.

AB - The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA- rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre- treatment prevented cocaine-induced ischemic changes, especially in these DA- rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.

KW - Brain blood flow

KW - Calcium channel antagonist

KW - Cocaine

KW - Human

KW - Ischemia

KW - Isradipine

KW - Quantitative SPECT

KW - Stroke

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ER -

Isradipine prevents global and regional cocaine-induced changes in brain blood flow: A preliminary study

Abstract

Keywords

ASJC Scopus subject areas

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