Isradipine prevents global and regional cocaine-induced changes in brain blood flow: A preliminary study

Bankole Johnson; Bruce Barron; Bing Fang; Lamk Lamki; Louis Wagner; Lynda Wells; Paul Kenny; Dennis Overton; Sukhindar Dhother; David Abramson; Richard Chen; Larry Kramer

doi:10.1007/s002130050575

Isradipine prevents global and regional cocaine-induced changes in brain blood flow: A preliminary study

Bankole Johnson^*, Bruce Barron, Bing Fang, Lamk Lamki, Louis Wagner, Lynda Wells, Paul Kenny, Dennis Overton, Sukhindar Dhother, David Abramson, Richard Chen, Larry Kramer

^*Corresponding author for this work

Radiology & Molecular Imaging

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA- rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre- treatment prevented cocaine-induced ischemic changes, especially in these DA- rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.

Original language	English
Pages (from-to)	335-341
Number of pages	7
Journal	Psychopharmacology
Volume	136
Issue number	4
DOIs	https://doi.org/10.1007/s002130050575
Publication status	Published - 1998

Keywords

Brain blood flow
Calcium channel antagonist
Cocaine
Human
Ischemia
Isradipine
Quantitative SPECT
Stroke

ASJC Scopus subject areas

Pharmacology

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10.1007/s002130050575

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Isradipine prevents global and regional cocaine-induced changes in brain blood flow : A preliminary study. / Johnson, Bankole; Barron, Bruce; Fang, Bing; Lamki, Lamk; Wagner, Louis; Wells, Lynda; Kenny, Paul; Overton, Dennis; Dhother, Sukhindar; Abramson, David; Chen, Richard; Kramer, Larry.

In: Psychopharmacology, Vol. 136, No. 4, 1998, p. 335-341.

Research output: Contribution to journal › Article › peer-review

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AU - Dhother, Sukhindar

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Isradipine prevents global and regional cocaine-induced changes in brain blood flow: A preliminary study

Abstract

Keywords

ASJC Scopus subject areas

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