Isradipine prevents global and regional cocaine-induced changes in brain blood flow: A preliminary study

Bankole Johnson, Bruce Barron, Bing Fang, Lamk Lamki, Louis Wagner, Lynda Wells, Paul Kenny, Dennis Overton, Sukhindar Dhother, David Abramson, Richard Chen, Larry Kramer

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20 Citations (Scopus)

Abstract

The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA- rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre- treatment prevented cocaine-induced ischemic changes, especially in these DA- rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalPsychopharmacology
Volume136
Issue number4
DOIs
Publication statusPublished - 1998

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Keywords

  • Brain blood flow
  • Calcium channel antagonist
  • Cocaine
  • Human
  • Ischemia
  • Isradipine
  • Quantitative SPECT
  • Stroke

ASJC Scopus subject areas

  • Pharmacology

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