Isradipine prevents global and regional cocaine-induced changes in brain blood flow: A preliminary study

Bankole Johnson, Bruce Barron, Bing Fang, Lamk Lamki, Louis Wagner, Lynda Wells, Paul Kenny, Dennis Overton, Sukhindar Dhother, David Abramson, Richard Chen, Larry Kramer

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA- rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre- treatment prevented cocaine-induced ischemic changes, especially in these DA- rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalPsychopharmacology
Volume136
Issue number4
DOIs
Publication statusPublished - 1998

Fingerprint

Isradipine
Cocaine
Brain
Dopamine
Brain Ischemia
L-Type Calcium Channels
Calcium Channel Blockers
Single-Photon Emission-Computed Tomography
Animal Models
Stroke

Keywords

  • Brain blood flow
  • Calcium channel antagonist
  • Cocaine
  • Human
  • Ischemia
  • Isradipine
  • Quantitative SPECT
  • Stroke

ASJC Scopus subject areas

  • Pharmacology

Cite this

Isradipine prevents global and regional cocaine-induced changes in brain blood flow : A preliminary study. / Johnson, Bankole; Barron, Bruce; Fang, Bing; Lamki, Lamk; Wagner, Louis; Wells, Lynda; Kenny, Paul; Overton, Dennis; Dhother, Sukhindar; Abramson, David; Chen, Richard; Kramer, Larry.

In: Psychopharmacology, Vol. 136, No. 4, 1998, p. 335-341.

Research output: Contribution to journalArticle

Johnson, B, Barron, B, Fang, B, Lamki, L, Wagner, L, Wells, L, Kenny, P, Overton, D, Dhother, S, Abramson, D, Chen, R & Kramer, L 1998, 'Isradipine prevents global and regional cocaine-induced changes in brain blood flow: A preliminary study', Psychopharmacology, vol. 136, no. 4, pp. 335-341. https://doi.org/10.1007/s002130050575
Johnson, Bankole ; Barron, Bruce ; Fang, Bing ; Lamki, Lamk ; Wagner, Louis ; Wells, Lynda ; Kenny, Paul ; Overton, Dennis ; Dhother, Sukhindar ; Abramson, David ; Chen, Richard ; Kramer, Larry. / Isradipine prevents global and regional cocaine-induced changes in brain blood flow : A preliminary study. In: Psychopharmacology. 1998 ; Vol. 136, No. 4. pp. 335-341.
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