TY - JOUR
T1 - Isochromosome 9q as a sole anomaly in an Omani boy with acute lymphoblastic leukaemia
AU - Achandira, Udayakumar Muthappa
AU - Pathare, Anil V.
AU - Al Kindi, Salam
AU - Dennison, David
AU - Al Yahyaee, Said
PY - 2009/4/28
Y1 - 2009/4/28
N2 - This report describes a case of acute lymphoblastic leukaemia in which isochromosome 9q (i(9q)) was the sole acquired cytogenetic abnormality. The Immunophenotype showed positivity for CD3, CD4, CD5, CD7, CD8, CD10, CD71, CD117 and TdT, consistent with T cell acute lymphoblastic leukaemia (ALL). The chromosomal analysis of bone marrow showed 46,XY,i(9)(q10) in all the metaphases analysed. The bone marrow morphology was ALL-L2 as per the French-American- British criteria. Isochromosomes are rare chromosomal abnormalities in childhood ALL and the effect of i(9q) is not well established. The patient's good response to therapy with normal cytogenetics within a month of induction, and disease-free survival after bone marrow transplant are indicative of a good prognosis in such cases.
AB - This report describes a case of acute lymphoblastic leukaemia in which isochromosome 9q (i(9q)) was the sole acquired cytogenetic abnormality. The Immunophenotype showed positivity for CD3, CD4, CD5, CD7, CD8, CD10, CD71, CD117 and TdT, consistent with T cell acute lymphoblastic leukaemia (ALL). The chromosomal analysis of bone marrow showed 46,XY,i(9)(q10) in all the metaphases analysed. The bone marrow morphology was ALL-L2 as per the French-American- British criteria. Isochromosomes are rare chromosomal abnormalities in childhood ALL and the effect of i(9q) is not well established. The patient's good response to therapy with normal cytogenetics within a month of induction, and disease-free survival after bone marrow transplant are indicative of a good prognosis in such cases.
UR - http://www.scopus.com/inward/record.url?scp=84896351406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896351406&partnerID=8YFLogxK
U2 - 10.1136/bcr.09.2008.0890
DO - 10.1136/bcr.09.2008.0890
M3 - Article
AN - SCOPUS:84896351406
SN - 1757-790X
JO - BMJ Case Reports
JF - BMJ Case Reports
ER -