Isochromosome 9q as a sole anomaly in an Omani boy with acute lymphoblastic leukaemia

Udayakumar Muthappa Achandira, Anil V. Pathare, Salam Al Kindi, David Dennison, Said Al Yahyaee

Research output: Contribution to journalArticle

Abstract

This report describes a case of acute lymphoblastic leukaemia in which isochromosome 9q (i(9q)) was the sole acquired cytogenetic abnormality. The Immunophenotype showed positivity for CD3, CD4, CD5, CD7, CD8, CD10, CD71, CD117 and TdT, consistent with T cell acute lymphoblastic leukaemia (ALL). The chromosomal analysis of bone marrow showed 46,XY,i(9)(q10) in all the metaphases analysed. The bone marrow morphology was ALL-L2 as per the French-American- British criteria. Isochromosomes are rare chromosomal abnormalities in childhood ALL and the effect of i(9q) is not well established. The patient's good response to therapy with normal cytogenetics within a month of induction, and disease-free survival after bone marrow transplant are indicative of a good prognosis in such cases.

Original languageEnglish
JournalBMJ Case Reports
DOIs
Publication statusPublished - Apr 28 2009

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Isochromosomes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Bone Marrow
Chromosome Aberrations
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Metaphase
Cytogenetics
Disease-Free Survival
Transplants
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Isochromosome 9q as a sole anomaly in an Omani boy with acute lymphoblastic leukaemia. / Achandira, Udayakumar Muthappa; Pathare, Anil V.; Al Kindi, Salam; Dennison, David; Al Yahyaee, Said.

In: BMJ Case Reports, 28.04.2009.

Research output: Contribution to journalArticle

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