Is low serum tocopherol in Wilson's disease a significant symptom?

Sanjib Sinha, Rita Christopher, G. R. Arunodaya, L. K. Prashanth, G. Gopinath, H. S. Swamy, A. B. Taly

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18 Citations (Scopus)

Abstract

Free radical mediated injury is increasingly recognized in many metabolic diseases including Wilson's disease (WD). Use of antioxidants as an adjunctive therapy in WD may have therapeutic significance. The aim of the study was to correlate serum levels of tocopherols with serum copper and ceruloplasmin and clinical status of these patients. Serum levels of tocopherol of were measured spectrophotometrically using the Emmerie-Engel reaction in 34 patients from a large cohort of WD being followed up at a tertiary care center. Majority of patients were male (M/F=23:11). The mean serum copper was 43.6±26.2 μg/dl (range=10-121 μg/dl) and serum ceruloplasmin was 5.6±5.5 mg/dl (range=0-30 mg/dl). The mean serum tocopherol level was 0.68±0.18 mg/dl (range=0.23-1.14 mg/dl) and compared to the control (1.07±0.17 mg/dl), nearly 59% of patients had decreased levels (p

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalJournal of the Neurological Sciences
Volume228
Issue number2
DOIs
Publication statusPublished - Feb 15 2005

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Keywords

  • Antioxidant
  • Correlation with other symptoms
  • Tocopherol
  • Wilson's disease

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Sinha, S., Christopher, R., Arunodaya, G. R., Prashanth, L. K., Gopinath, G., Swamy, H. S., & Taly, A. B. (2005). Is low serum tocopherol in Wilson's disease a significant symptom? Journal of the Neurological Sciences, 228(2), 121-123. https://doi.org/10.1016/j.jns.2004.10.017