Abstract
Free radical mediated injury is increasingly recognized in many metabolic diseases including Wilson's disease (WD). Use of antioxidants as an adjunctive therapy in WD may have therapeutic significance. The aim of the study was to correlate serum levels of tocopherols with serum copper and ceruloplasmin and clinical status of these patients. Serum levels of tocopherol of were measured spectrophotometrically using the Emmerie-Engel reaction in 34 patients from a large cohort of WD being followed up at a tertiary care center. Majority of patients were male (M/F=23:11). The mean serum copper was 43.6±26.2 μg/dl (range=10-121 μg/dl) and serum ceruloplasmin was 5.6±5.5 mg/dl (range=0-30 mg/dl). The mean serum tocopherol level was 0.68±0.18 mg/dl (range=0.23-1.14 mg/dl) and compared to the control (1.07±0.17 mg/dl), nearly 59% of patients had decreased levels (p
| Original language | English |
|---|---|
| Pages (from-to) | 121-123 |
| Number of pages | 3 |
| Journal | Journal of the Neurological Sciences |
| Volume | 228 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 15 2005 |
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Keywords
- Antioxidant
- Correlation with other symptoms
- Tocopherol
- Wilson's disease
ASJC Scopus subject areas
- Ageing
- Clinical Neurology
- Surgery
- Developmental Neuroscience
- Neurology
- Neuroscience(all)
Cite this
Is low serum tocopherol in Wilson's disease a significant symptom? / Sinha, Sanjib; Christopher, Rita; Arunodaya, G. R.; Prashanth, L. K.; Gopinath, G.; Swamy, H. S.; Taly, A. B.
In: Journal of the Neurological Sciences, Vol. 228, No. 2, 15.02.2005, p. 121-123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is low serum tocopherol in Wilson's disease a significant symptom?
AU - Sinha, Sanjib
AU - Christopher, Rita
AU - Arunodaya, G. R.
AU - Prashanth, L. K.
AU - Gopinath, G.
AU - Swamy, H. S.
AU - Taly, A. B.
PY - 2005/2/15
Y1 - 2005/2/15
N2 - Free radical mediated injury is increasingly recognized in many metabolic diseases including Wilson's disease (WD). Use of antioxidants as an adjunctive therapy in WD may have therapeutic significance. The aim of the study was to correlate serum levels of tocopherols with serum copper and ceruloplasmin and clinical status of these patients. Serum levels of tocopherol of were measured spectrophotometrically using the Emmerie-Engel reaction in 34 patients from a large cohort of WD being followed up at a tertiary care center. Majority of patients were male (M/F=23:11). The mean serum copper was 43.6±26.2 μg/dl (range=10-121 μg/dl) and serum ceruloplasmin was 5.6±5.5 mg/dl (range=0-30 mg/dl). The mean serum tocopherol level was 0.68±0.18 mg/dl (range=0.23-1.14 mg/dl) and compared to the control (1.07±0.17 mg/dl), nearly 59% of patients had decreased levels (p
AB - Free radical mediated injury is increasingly recognized in many metabolic diseases including Wilson's disease (WD). Use of antioxidants as an adjunctive therapy in WD may have therapeutic significance. The aim of the study was to correlate serum levels of tocopherols with serum copper and ceruloplasmin and clinical status of these patients. Serum levels of tocopherol of were measured spectrophotometrically using the Emmerie-Engel reaction in 34 patients from a large cohort of WD being followed up at a tertiary care center. Majority of patients were male (M/F=23:11). The mean serum copper was 43.6±26.2 μg/dl (range=10-121 μg/dl) and serum ceruloplasmin was 5.6±5.5 mg/dl (range=0-30 mg/dl). The mean serum tocopherol level was 0.68±0.18 mg/dl (range=0.23-1.14 mg/dl) and compared to the control (1.07±0.17 mg/dl), nearly 59% of patients had decreased levels (p
KW - Antioxidant
KW - Correlation with other symptoms
KW - Tocopherol
KW - Wilson's disease
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UR - http://www.scopus.com/inward/citedby.url?scp=13444282362&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2004.10.017
DO - 10.1016/j.jns.2004.10.017
M3 - Article
VL - 228
SP - 121
EP - 123
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 2
ER -