TY - JOUR
T1 - Iridium-Catalyzed Borylation of 6-Fluoroquinolines
T2 - Access to 6-Fluoroquinolones
AU - Hickey, Aobha
AU - Merz, Julia
AU - Al Mamari, Hamad H.
AU - Friedrich, Alexandra
AU - Marder, Todd B.
AU - McGlacken, Gerard P.
N1 - Funding Information:
GMG thanks the Irish Research Council for funding (IRC GOIPG/2017/255), the Science Foundation Ireland (grant number SFI/12/IP/1315), and the Synthesis and Solid State Pharmaceutical Centre (SSPC) (SFI/12/RC/2275 and SFI/12/RC2275_P2). TBM thanks the Julius-Maximilians-Universität Würzburg. Sabbatical leave granted to HAM by Sultan Qaboos University is gratefully acknowledged.
Publisher Copyright:
©
PY - 2022
Y1 - 2022
N2 - The Ir-catalyzed C-H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolonethe core structure of many antibiotics.
AB - The Ir-catalyzed C-H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolonethe core structure of many antibiotics.
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U2 - 10.1021/acs.joc.2c00973
DO - 10.1021/acs.joc.2c00973
M3 - Article
C2 - 35839386
AN - SCOPUS:85135565424
SN - 0022-3263
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
ER -