Ion-association method for the spectrophotometric determination of the antitussive drug noscapine

Bahruddin Saad, Salah M. Sultan, F. E O Suliman

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Abstract

A simple, sensitive and fairly rapid method for the determination of noscapine is described, based on the measurement of the absorbance of the organic soluble ion-association complex formed between the noscapine monocation and a bulky counter anion. Methyl Orange, Bromothymol Blue and Bromocresol Green (BCG) were examined as counter ions. The effect of few solvents, the counter-ion concentration and pH on the extraction were also investigated. The most suitable system was based on BCG (pH 3.0) with chloroform as the extraction solvent. The use of the other counter ions, in conjuction with their respective solvents, was found to be less sensitive. The BCG system exhibits negligible or no interference when used for the determination of 38 ppm of noscapine in the presence of several drug excipients, thus lending itself as a possible procedure for the determination of this alkaloid in pharmaceutical preparations.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalTalanta
Volume44
Issue number1
DOIs
Publication statusPublished - Jan 1997

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Keywords

  • Bromoscresol Green
  • Drug formulations
  • Extraction
  • Ion association
  • Noscapine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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