International survey of T2* cardiovascular magnetic resonance in β-thalassemia major

John Paul Carpenter, Michael Roughton, Dudley J. Pennell, Taigang He, Paul Kirk, Lisa J. Anderson, V. John B Porter, J. Malcolm Walker, Renzo Galanello, Fabrice Danjou, Gianluca Forni, Antonis Kattamis, Vassilis Ladis, Marouso Drossou, Demetra Vini, Andreas Michos, Vassilios Perifanis, Tuncay Hazirolan, Ana Almeida, Yesim Aydinok & 31 others Selen Bayraktaroglu, Mirella Rangelova, Denka Stoyanova, Valeria Kaleva, Georgi Tonev, Amal El-Beshlawy, Mohsen Elalfy, Ibrahim Al-Nasser, Wing Yan Au, Shau Yin Ha, Chi Kong Li, Winnie Chiu-Wing Chu, Lee Lee Chan, Meng Yao Lu, Lia Wahidiyat, Manuela Merelles-Pulcini, Juliano de Lara Fernandes, Fernando Kay, P. Joy Ho, Jane S. Hankins, Maria Cappellini, Shahina Daar, Jameela Sathar, Ali Taher, George Kontoghiorges, Khawla Belhoul, Alexis Thompson, Janet L. Kwiatkowski, Ru San Tan, Isabelle Thuret, Catherine Badens

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Accumulation of myocardial iron is the cause of heart failure and early death in most transfused thalassemia major patients. T2* cardiovascular magnetic resonance provides calibrated, reproducible measurements of myocardial iron. However, there are few data regarding myocardial iron loading and its relation to outcome across the world. A survey is reported of 3,095 patients in 27 worldwide centers using T2* cardiovascular magnetic resonance. Data on baseline T2* and numbers of patients with symptoms of heart failure at first scan (defined as symptoms and signs of heart failure with objective evidence of left ventricular dysfunction) were requested together with more detailed information about patients who subsequently developed heart failure or died. At first scan, 20.6% had severe myocardial iron (T2*≤10ms), 22.8% had moderate myocardial iron (T2* 10-20ms) and 56.6% of patients had no iron loading (T2*>20ms). There was significant geographical variation in myocardial iron loading (24.8-52.6%; P

Original languageEnglish
Pages (from-to)1368-1374
Number of pages7
JournalHaematologica
Volume98
Issue number9
DOIs
Publication statusPublished - Sep 1 2013

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beta-Thalassemia
Magnetic Resonance Spectroscopy
Iron
Heart Failure
Left Ventricular Dysfunction
Surveys and Questionnaires
Signs and Symptoms

ASJC Scopus subject areas

  • Hematology

Cite this

Carpenter, J. P., Roughton, M., Pennell, D. J., He, T., Kirk, P., Anderson, L. J., ... Badens, C. (2013). International survey of T2* cardiovascular magnetic resonance in β-thalassemia major. Haematologica, 98(9), 1368-1374. https://doi.org/10.3324/haematol.2013.083634

International survey of T2* cardiovascular magnetic resonance in β-thalassemia major. / Carpenter, John Paul; Roughton, Michael; Pennell, Dudley J.; He, Taigang; Kirk, Paul; Anderson, Lisa J.; Porter, V. John B; Malcolm Walker, J.; Galanello, Renzo; Danjou, Fabrice; Forni, Gianluca; Kattamis, Antonis; Ladis, Vassilis; Drossou, Marouso; Vini, Demetra; Michos, Andreas; Perifanis, Vassilios; Hazirolan, Tuncay; Almeida, Ana; Aydinok, Yesim; Bayraktaroglu, Selen; Rangelova, Mirella; Stoyanova, Denka; Kaleva, Valeria; Tonev, Georgi; El-Beshlawy, Amal; Elalfy, Mohsen; Al-Nasser, Ibrahim; Au, Wing Yan; Ha, Shau Yin; Li, Chi Kong; Chiu-Wing Chu, Winnie; Chan, Lee Lee; Lu, Meng Yao; Wahidiyat, Lia; Merelles-Pulcini, Manuela; Fernandes, Juliano de Lara; Kay, Fernando; Joy Ho, P.; Hankins, Jane S.; Cappellini, Maria; Daar, Shahina; Sathar, Jameela; Taher, Ali; Kontoghiorges, George; Belhoul, Khawla; Thompson, Alexis; Kwiatkowski, Janet L.; Tan, Ru San; Thuret, Isabelle; Badens, Catherine.

In: Haematologica, Vol. 98, No. 9, 01.09.2013, p. 1368-1374.

Research output: Contribution to journalArticle

Carpenter, JP, Roughton, M, Pennell, DJ, He, T, Kirk, P, Anderson, LJ, Porter, VJB, Malcolm Walker, J, Galanello, R, Danjou, F, Forni, G, Kattamis, A, Ladis, V, Drossou, M, Vini, D, Michos, A, Perifanis, V, Hazirolan, T, Almeida, A, Aydinok, Y, Bayraktaroglu, S, Rangelova, M, Stoyanova, D, Kaleva, V, Tonev, G, El-Beshlawy, A, Elalfy, M, Al-Nasser, I, Au, WY, Ha, SY, Li, CK, Chiu-Wing Chu, W, Chan, LL, Lu, MY, Wahidiyat, L, Merelles-Pulcini, M, Fernandes, JDL, Kay, F, Joy Ho, P, Hankins, JS, Cappellini, M, Daar, S, Sathar, J, Taher, A, Kontoghiorges, G, Belhoul, K, Thompson, A, Kwiatkowski, JL, Tan, RS, Thuret, I & Badens, C 2013, 'International survey of T2* cardiovascular magnetic resonance in β-thalassemia major', Haematologica, vol. 98, no. 9, pp. 1368-1374. https://doi.org/10.3324/haematol.2013.083634
Carpenter JP, Roughton M, Pennell DJ, He T, Kirk P, Anderson LJ et al. International survey of T2* cardiovascular magnetic resonance in β-thalassemia major. Haematologica. 2013 Sep 1;98(9):1368-1374. https://doi.org/10.3324/haematol.2013.083634
Carpenter, John Paul ; Roughton, Michael ; Pennell, Dudley J. ; He, Taigang ; Kirk, Paul ; Anderson, Lisa J. ; Porter, V. John B ; Malcolm Walker, J. ; Galanello, Renzo ; Danjou, Fabrice ; Forni, Gianluca ; Kattamis, Antonis ; Ladis, Vassilis ; Drossou, Marouso ; Vini, Demetra ; Michos, Andreas ; Perifanis, Vassilios ; Hazirolan, Tuncay ; Almeida, Ana ; Aydinok, Yesim ; Bayraktaroglu, Selen ; Rangelova, Mirella ; Stoyanova, Denka ; Kaleva, Valeria ; Tonev, Georgi ; El-Beshlawy, Amal ; Elalfy, Mohsen ; Al-Nasser, Ibrahim ; Au, Wing Yan ; Ha, Shau Yin ; Li, Chi Kong ; Chiu-Wing Chu, Winnie ; Chan, Lee Lee ; Lu, Meng Yao ; Wahidiyat, Lia ; Merelles-Pulcini, Manuela ; Fernandes, Juliano de Lara ; Kay, Fernando ; Joy Ho, P. ; Hankins, Jane S. ; Cappellini, Maria ; Daar, Shahina ; Sathar, Jameela ; Taher, Ali ; Kontoghiorges, George ; Belhoul, Khawla ; Thompson, Alexis ; Kwiatkowski, Janet L. ; Tan, Ru San ; Thuret, Isabelle ; Badens, Catherine. / International survey of T2* cardiovascular magnetic resonance in β-thalassemia major. In: Haematologica. 2013 ; Vol. 98, No. 9. pp. 1368-1374.
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