Interim18 F-FLUORO-2-deoxy-d-glucose positron emission tomography scan/computed tomography scan in diffuse large B cell lymphoma-as a prognostic tool

Abdul Basit, Neelam Siddiqui, Narjis Muzaffar, Umme Kalsoom Awan, Humayun Bashir, Sardar Ali Khan, Abdul Hameed

Research output: Contribution to journalArticle

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Abstract

Objective: To assess the role of interim [18F]-Fluoro-2-deoxy-d-glucose positron emission tomography scan/computed tomography scan in the management of diffuse large B-cell lymphoma in terms of progression-free survival and overall survival prediction. Methods: The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital, Lahore, and comprised data of newly diagnosed patients of diffuse large B-cell lymphoma treated between January 2010 and June 2013.Baseline characteristics of patients were documented and compared. Response on interim positron emission tomography/computed tomography and end of treatment scan was taken a look at, and. progression-free survival and overall survival for positive/negative scans were calculated. Data was also reviewed for sensitivity, specificity, positive predictive value and negative predictive value for relapse. SPSS 19 was used for statistical analysis. Results: Data of 119 patients was reviewed, and 87(73%) of them were males. Overall median age was 33 years (range 18-50). Interim scan was positive for 63(53%) patients and negative for 53(47%), and showed positive predictive value, negative predictive value, sensitivity and specificity for relapse of 35%, 89%, 79% and 55% respectively. Two-years progression-free survival and overall survival for scan-positive patients was 66% and 72% compared to 88% (p=0.002) and 92% (p=0.005) for scan-negative patients. Corresponding values at 2 years for patients having positive end-of-treatment scan were 35% and 44% against 94% (p<0.001) and 96%(p<0.001) for patients with negative scan. Conclusion: Interim positron emission tomography/computed tomography had high sensitivity and negative predictive value for relapse in diffuse large B-cell lymphoma. Both interim and end-of-treatment scans were predictors of progression-free survival and overall survival.

Original languageEnglish
Pages (from-to)380-386
Number of pages7
JournalJournal of the Pakistan Medical Association
Volume66
Issue number4
Publication statusPublished - Apr 1 2016

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Lymphoma, Large B-Cell, Diffuse
Glucose
Disease-Free Survival
Survival
Recurrence
Cancer Care Facilities
Sensitivity and Specificity
Positron Emission Tomography Computed Tomography
Therapeutics
Retrospective Studies

Keywords

  • Computed tomography
  • Diffuse large B-cell lymphoma
  • Positron emission tomography
  • Survival analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Interim18 F-FLUORO-2-deoxy-d-glucose positron emission tomography scan/computed tomography scan in diffuse large B cell lymphoma-as a prognostic tool. / Basit, Abdul; Siddiqui, Neelam; Muzaffar, Narjis; Awan, Umme Kalsoom; Bashir, Humayun; Khan, Sardar Ali; Hameed, Abdul.

In: Journal of the Pakistan Medical Association, Vol. 66, No. 4, 01.04.2016, p. 380-386.

Research output: Contribution to journalArticle

Basit, Abdul ; Siddiqui, Neelam ; Muzaffar, Narjis ; Awan, Umme Kalsoom ; Bashir, Humayun ; Khan, Sardar Ali ; Hameed, Abdul. / Interim18 F-FLUORO-2-deoxy-d-glucose positron emission tomography scan/computed tomography scan in diffuse large B cell lymphoma-as a prognostic tool. In: Journal of the Pakistan Medical Association. 2016 ; Vol. 66, No. 4. pp. 380-386.
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abstract = "Objective: To assess the role of interim [18F]-Fluoro-2-deoxy-d-glucose positron emission tomography scan/computed tomography scan in the management of diffuse large B-cell lymphoma in terms of progression-free survival and overall survival prediction. Methods: The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital, Lahore, and comprised data of newly diagnosed patients of diffuse large B-cell lymphoma treated between January 2010 and June 2013.Baseline characteristics of patients were documented and compared. Response on interim positron emission tomography/computed tomography and end of treatment scan was taken a look at, and. progression-free survival and overall survival for positive/negative scans were calculated. Data was also reviewed for sensitivity, specificity, positive predictive value and negative predictive value for relapse. SPSS 19 was used for statistical analysis. Results: Data of 119 patients was reviewed, and 87(73{\%}) of them were males. Overall median age was 33 years (range 18-50). Interim scan was positive for 63(53{\%}) patients and negative for 53(47{\%}), and showed positive predictive value, negative predictive value, sensitivity and specificity for relapse of 35{\%}, 89{\%}, 79{\%} and 55{\%} respectively. Two-years progression-free survival and overall survival for scan-positive patients was 66{\%} and 72{\%} compared to 88{\%} (p=0.002) and 92{\%} (p=0.005) for scan-negative patients. Corresponding values at 2 years for patients having positive end-of-treatment scan were 35{\%} and 44{\%} against 94{\%} (p<0.001) and 96{\%}(p<0.001) for patients with negative scan. Conclusion: Interim positron emission tomography/computed tomography had high sensitivity and negative predictive value for relapse in diffuse large B-cell lymphoma. Both interim and end-of-treatment scans were predictors of progression-free survival and overall survival.",
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T1 - Interim18 F-FLUORO-2-deoxy-d-glucose positron emission tomography scan/computed tomography scan in diffuse large B cell lymphoma-as a prognostic tool

AU - Basit, Abdul

AU - Siddiqui, Neelam

AU - Muzaffar, Narjis

AU - Awan, Umme Kalsoom

AU - Bashir, Humayun

AU - Khan, Sardar Ali

AU - Hameed, Abdul

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N2 - Objective: To assess the role of interim [18F]-Fluoro-2-deoxy-d-glucose positron emission tomography scan/computed tomography scan in the management of diffuse large B-cell lymphoma in terms of progression-free survival and overall survival prediction. Methods: The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital, Lahore, and comprised data of newly diagnosed patients of diffuse large B-cell lymphoma treated between January 2010 and June 2013.Baseline characteristics of patients were documented and compared. Response on interim positron emission tomography/computed tomography and end of treatment scan was taken a look at, and. progression-free survival and overall survival for positive/negative scans were calculated. Data was also reviewed for sensitivity, specificity, positive predictive value and negative predictive value for relapse. SPSS 19 was used for statistical analysis. Results: Data of 119 patients was reviewed, and 87(73%) of them were males. Overall median age was 33 years (range 18-50). Interim scan was positive for 63(53%) patients and negative for 53(47%), and showed positive predictive value, negative predictive value, sensitivity and specificity for relapse of 35%, 89%, 79% and 55% respectively. Two-years progression-free survival and overall survival for scan-positive patients was 66% and 72% compared to 88% (p=0.002) and 92% (p=0.005) for scan-negative patients. Corresponding values at 2 years for patients having positive end-of-treatment scan were 35% and 44% against 94% (p<0.001) and 96%(p<0.001) for patients with negative scan. Conclusion: Interim positron emission tomography/computed tomography had high sensitivity and negative predictive value for relapse in diffuse large B-cell lymphoma. Both interim and end-of-treatment scans were predictors of progression-free survival and overall survival.

AB - Objective: To assess the role of interim [18F]-Fluoro-2-deoxy-d-glucose positron emission tomography scan/computed tomography scan in the management of diffuse large B-cell lymphoma in terms of progression-free survival and overall survival prediction. Methods: The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital, Lahore, and comprised data of newly diagnosed patients of diffuse large B-cell lymphoma treated between January 2010 and June 2013.Baseline characteristics of patients were documented and compared. Response on interim positron emission tomography/computed tomography and end of treatment scan was taken a look at, and. progression-free survival and overall survival for positive/negative scans were calculated. Data was also reviewed for sensitivity, specificity, positive predictive value and negative predictive value for relapse. SPSS 19 was used for statistical analysis. Results: Data of 119 patients was reviewed, and 87(73%) of them were males. Overall median age was 33 years (range 18-50). Interim scan was positive for 63(53%) patients and negative for 53(47%), and showed positive predictive value, negative predictive value, sensitivity and specificity for relapse of 35%, 89%, 79% and 55% respectively. Two-years progression-free survival and overall survival for scan-positive patients was 66% and 72% compared to 88% (p=0.002) and 92% (p=0.005) for scan-negative patients. Corresponding values at 2 years for patients having positive end-of-treatment scan were 35% and 44% against 94% (p<0.001) and 96%(p<0.001) for patients with negative scan. Conclusion: Interim positron emission tomography/computed tomography had high sensitivity and negative predictive value for relapse in diffuse large B-cell lymphoma. Both interim and end-of-treatment scans were predictors of progression-free survival and overall survival.

KW - Computed tomography

KW - Diffuse large B-cell lymphoma

KW - Positron emission tomography

KW - Survival analysis

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