Insights into organoid-based modeling of COVID-19 pathology

Mohadese Hashem Boroojerdi; Tariq Al Jabry; Seyed Mohamad Javad Mirarefin; Halima Albalushi

doi:10.1186/s12985-023-01996-2

Insights into organoid-based modeling of COVID-19 pathology

Mohadese Hashem Boroojerdi, Tariq Al Jabry, Seyed Mohamad Javad Mirarefin, Halima Albalushi^*

^*Corresponding author for this work

Human & Clinical Anatomy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.

Original language	English
Article number	37
Pages (from-to)	37
Journal	Virology Journal
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12985-023-01996-2
Publication status	Published - Feb 25 2023

Keywords

COVID-19
Organoid
Regenerative medicine
SARS-CoV-2
Stem cell
COVID-19 Drug Treatment
Organoids
Humans

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12985-023-01996-2

Cite this

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abstract = "Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.",

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AU - Albalushi, Halima

PY - 2023/2/25

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Insights into organoid-based modeling of COVID-19 pathology

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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