Influence of variable bifurcation angulation and outflow boundary conditions in 3D finite element modelling of left coronary artery on coronary diagnostic parameter

Kalimuthu Govindaraju, Irfan Anjum Badruddin, Girish N. Viswanathan, Sarfaraz Kamangar, N. J. Salman Ahmed, Abdullah A.A.A. Al-Rashed

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Theoretical impact of left coronary bifurcation angulation (BA) variations and percentage of flow distribution variations (FDV) in coronary artery branches (CAB) on anatomic assessment of bifurcated lesions, is investigated by considering fractional flow reserve (FFR) as a standard diagnostic parameter. According to Medina classification, computational models of coronary bifurcation lesions types of (1, 0, 0), (0, 1, 0) and (0, 0, 1) were developed. The models included BA of 30°, 45°, 60°, 75°, 90° and 120°. Computational fluid dynamics analysis was performed under hyperaemic flow condition and FFR was evaluated with percentage of FDV in CAB. For any fixed percentage of flow in the CAB and change in BA, FFR was significantly affected in the lesion type (1, 0, 0) whereas no significance was found in the lesion types (0, 1, 0) and (0, 0, 1). Percentage of FDV in CAB for any fixed BA significantly altered FFR in all the lesion types. Overall, 5%, 41% and 73% variations in FFR were found in (1, 0, 0), (0, 1, 0) and (0, 0, 1) respectively. The variation of BA could not be neglected in in vitro anatomical assessment for lesion type (1, 0, 0) but not in case of (0, 1, 0) and (0, 0, 1). Nevertheless, percentage of FDV in CAB is significantly altered FFR in the left coronary bifurcation lesions, which lead to underestimation of stenosis severity and postponement of coronary interventional procedure.

Original languageEnglish
Pages (from-to)368-374
Number of pages7
JournalCurrent Science
Volume111
Issue number2
DOIs
Publication statusPublished - 2016

Fingerprint

Coronary Vessels
Hydrodynamics
Pathologic Constriction

Keywords

  • Bifurcation angulation
  • Computational fluid dynamics
  • Coronary branch flow
  • FFR
  • Left coronary artery

ASJC Scopus subject areas

  • General

Cite this

Influence of variable bifurcation angulation and outflow boundary conditions in 3D finite element modelling of left coronary artery on coronary diagnostic parameter. / Govindaraju, Kalimuthu; Badruddin, Irfan Anjum; Viswanathan, Girish N.; Kamangar, Sarfaraz; Salman Ahmed, N. J.; Al-Rashed, Abdullah A.A.A.

In: Current Science, Vol. 111, No. 2, 2016, p. 368-374.

Research output: Contribution to journalArticle

Govindaraju, Kalimuthu ; Badruddin, Irfan Anjum ; Viswanathan, Girish N. ; Kamangar, Sarfaraz ; Salman Ahmed, N. J. ; Al-Rashed, Abdullah A.A.A. / Influence of variable bifurcation angulation and outflow boundary conditions in 3D finite element modelling of left coronary artery on coronary diagnostic parameter. In: Current Science. 2016 ; Vol. 111, No. 2. pp. 368-374.
@article{c9b164d6d8a7475eb059fd5d1e821f87,
title = "Influence of variable bifurcation angulation and outflow boundary conditions in 3D finite element modelling of left coronary artery on coronary diagnostic parameter",
abstract = "Theoretical impact of left coronary bifurcation angulation (BA) variations and percentage of flow distribution variations (FDV) in coronary artery branches (CAB) on anatomic assessment of bifurcated lesions, is investigated by considering fractional flow reserve (FFR) as a standard diagnostic parameter. According to Medina classification, computational models of coronary bifurcation lesions types of (1, 0, 0), (0, 1, 0) and (0, 0, 1) were developed. The models included BA of 30°, 45°, 60°, 75°, 90° and 120°. Computational fluid dynamics analysis was performed under hyperaemic flow condition and FFR was evaluated with percentage of FDV in CAB. For any fixed percentage of flow in the CAB and change in BA, FFR was significantly affected in the lesion type (1, 0, 0) whereas no significance was found in the lesion types (0, 1, 0) and (0, 0, 1). Percentage of FDV in CAB for any fixed BA significantly altered FFR in all the lesion types. Overall, 5{\%}, 41{\%} and 73{\%} variations in FFR were found in (1, 0, 0), (0, 1, 0) and (0, 0, 1) respectively. The variation of BA could not be neglected in in vitro anatomical assessment for lesion type (1, 0, 0) but not in case of (0, 1, 0) and (0, 0, 1). Nevertheless, percentage of FDV in CAB is significantly altered FFR in the left coronary bifurcation lesions, which lead to underestimation of stenosis severity and postponement of coronary interventional procedure.",
keywords = "Bifurcation angulation, Computational fluid dynamics, Coronary branch flow, FFR, Left coronary artery",
author = "Kalimuthu Govindaraju and Badruddin, {Irfan Anjum} and Viswanathan, {Girish N.} and Sarfaraz Kamangar and {Salman Ahmed}, {N. J.} and Al-Rashed, {Abdullah A.A.A.}",
year = "2016",
doi = "10.18520/cs/v111/i2/368-374",
language = "English",
volume = "111",
pages = "368--374",
journal = "Current Science",
issn = "0011-3891",
publisher = "Indian Academy of Sciences",
number = "2",

}

TY - JOUR

T1 - Influence of variable bifurcation angulation and outflow boundary conditions in 3D finite element modelling of left coronary artery on coronary diagnostic parameter

AU - Govindaraju, Kalimuthu

AU - Badruddin, Irfan Anjum

AU - Viswanathan, Girish N.

AU - Kamangar, Sarfaraz

AU - Salman Ahmed, N. J.

AU - Al-Rashed, Abdullah A.A.A.

PY - 2016

Y1 - 2016

N2 - Theoretical impact of left coronary bifurcation angulation (BA) variations and percentage of flow distribution variations (FDV) in coronary artery branches (CAB) on anatomic assessment of bifurcated lesions, is investigated by considering fractional flow reserve (FFR) as a standard diagnostic parameter. According to Medina classification, computational models of coronary bifurcation lesions types of (1, 0, 0), (0, 1, 0) and (0, 0, 1) were developed. The models included BA of 30°, 45°, 60°, 75°, 90° and 120°. Computational fluid dynamics analysis was performed under hyperaemic flow condition and FFR was evaluated with percentage of FDV in CAB. For any fixed percentage of flow in the CAB and change in BA, FFR was significantly affected in the lesion type (1, 0, 0) whereas no significance was found in the lesion types (0, 1, 0) and (0, 0, 1). Percentage of FDV in CAB for any fixed BA significantly altered FFR in all the lesion types. Overall, 5%, 41% and 73% variations in FFR were found in (1, 0, 0), (0, 1, 0) and (0, 0, 1) respectively. The variation of BA could not be neglected in in vitro anatomical assessment for lesion type (1, 0, 0) but not in case of (0, 1, 0) and (0, 0, 1). Nevertheless, percentage of FDV in CAB is significantly altered FFR in the left coronary bifurcation lesions, which lead to underestimation of stenosis severity and postponement of coronary interventional procedure.

AB - Theoretical impact of left coronary bifurcation angulation (BA) variations and percentage of flow distribution variations (FDV) in coronary artery branches (CAB) on anatomic assessment of bifurcated lesions, is investigated by considering fractional flow reserve (FFR) as a standard diagnostic parameter. According to Medina classification, computational models of coronary bifurcation lesions types of (1, 0, 0), (0, 1, 0) and (0, 0, 1) were developed. The models included BA of 30°, 45°, 60°, 75°, 90° and 120°. Computational fluid dynamics analysis was performed under hyperaemic flow condition and FFR was evaluated with percentage of FDV in CAB. For any fixed percentage of flow in the CAB and change in BA, FFR was significantly affected in the lesion type (1, 0, 0) whereas no significance was found in the lesion types (0, 1, 0) and (0, 0, 1). Percentage of FDV in CAB for any fixed BA significantly altered FFR in all the lesion types. Overall, 5%, 41% and 73% variations in FFR were found in (1, 0, 0), (0, 1, 0) and (0, 0, 1) respectively. The variation of BA could not be neglected in in vitro anatomical assessment for lesion type (1, 0, 0) but not in case of (0, 1, 0) and (0, 0, 1). Nevertheless, percentage of FDV in CAB is significantly altered FFR in the left coronary bifurcation lesions, which lead to underestimation of stenosis severity and postponement of coronary interventional procedure.

KW - Bifurcation angulation

KW - Computational fluid dynamics

KW - Coronary branch flow

KW - FFR

KW - Left coronary artery

UR - http://www.scopus.com/inward/record.url?scp=84989249033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989249033&partnerID=8YFLogxK

U2 - 10.18520/cs/v111/i2/368-374

DO - 10.18520/cs/v111/i2/368-374

M3 - Article

AN - SCOPUS:84989249033

VL - 111

SP - 368

EP - 374

JO - Current Science

JF - Current Science

SN - 0011-3891

IS - 2

ER -