TY - JOUR
T1 - Influence of urocortin and corticotropin releasing factor on venous tone in conscious rats
AU - Abdelrahman, Aly M.
AU - Lim, Su Lin
AU - Pang, Catherine C.Y.
N1 - Funding Information:
This work is supported by the Heart and Stroke Foundation of B.C. and Yukon.
PY - 2005/3/7
Y1 - 2005/3/7
N2 - The corticotropin releasing factor (CRF) family includes CRF and urocortin. The effects of urocortin and CRF (0.3, 1, 3 and 10 nmol/kg, i.v.) relative to those of vehicle (0.9% NaCl) on mean arterial pressure and mean circulatory filling pressure (index of venous tone) were examined in conscious, unrestrained rats that were either intact (unblocked) or ganglion-blocked by treatment with mecamylamine (10 mg/kg, i.v.) followed by noradrenaline (4 μg/kg/min, i.v.) to increase vasomotor tone. Both urocortin and CRF dose-dependently decreased mean arterial pressure in intact rats and ganglion-blocked rats. The depressor action of urocortin was greater than that of CRF at all doses. In intact rats, neither compound reduced mean circulatory filling pressure. In ganglion-blocked rats, urocortin and the highest dose of CRF decreased mean circulatory filling pressure. In conclusion, both urocortin and CRF are vasodepressor agents with venodilator action.
AB - The corticotropin releasing factor (CRF) family includes CRF and urocortin. The effects of urocortin and CRF (0.3, 1, 3 and 10 nmol/kg, i.v.) relative to those of vehicle (0.9% NaCl) on mean arterial pressure and mean circulatory filling pressure (index of venous tone) were examined in conscious, unrestrained rats that were either intact (unblocked) or ganglion-blocked by treatment with mecamylamine (10 mg/kg, i.v.) followed by noradrenaline (4 μg/kg/min, i.v.) to increase vasomotor tone. Both urocortin and CRF dose-dependently decreased mean arterial pressure in intact rats and ganglion-blocked rats. The depressor action of urocortin was greater than that of CRF at all doses. In intact rats, neither compound reduced mean circulatory filling pressure. In ganglion-blocked rats, urocortin and the highest dose of CRF decreased mean circulatory filling pressure. In conclusion, both urocortin and CRF are vasodepressor agents with venodilator action.
KW - Capacitance vessel
KW - Corticotropin releasing factor
KW - Mean arterial pressure
KW - Mean circulatory filling pressure
KW - Urocortin
KW - Venous
UR - http://www.scopus.com/inward/record.url?scp=14644388102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14644388102&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2005.01.022
DO - 10.1016/j.ejphar.2005.01.022
M3 - Article
C2 - 15740730
AN - SCOPUS:14644388102
SN - 0014-2999
VL - 510
SP - 107
EP - 111
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-2
ER -