Influence of urocortin and corticotropin releasing factor on venous tone in conscious rats

Aly M. Abdelrahman, Su Lin Lim, Catherine C.Y. Pang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The corticotropin releasing factor (CRF) family includes CRF and urocortin. The effects of urocortin and CRF (0.3, 1, 3 and 10 nmol/kg, i.v.) relative to those of vehicle (0.9% NaCl) on mean arterial pressure and mean circulatory filling pressure (index of venous tone) were examined in conscious, unrestrained rats that were either intact (unblocked) or ganglion-blocked by treatment with mecamylamine (10 mg/kg, i.v.) followed by noradrenaline (4 μg/kg/min, i.v.) to increase vasomotor tone. Both urocortin and CRF dose-dependently decreased mean arterial pressure in intact rats and ganglion-blocked rats. The depressor action of urocortin was greater than that of CRF at all doses. In intact rats, neither compound reduced mean circulatory filling pressure. In ganglion-blocked rats, urocortin and the highest dose of CRF decreased mean circulatory filling pressure. In conclusion, both urocortin and CRF are vasodepressor agents with venodilator action.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalEuropean Journal of Pharmacology
Volume510
Issue number1-2
DOIs
Publication statusPublished - Mar 7 2005

Keywords

  • Capacitance vessel
  • Corticotropin releasing factor
  • Mean arterial pressure
  • Mean circulatory filling pressure
  • Urocortin
  • Venous

ASJC Scopus subject areas

  • Pharmacology

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