Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats

Badreldin H. Ali, Ali A. Al-Qarawi, Osama M. Mahmoud, Mahmoud Hashad

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3 Citations (Scopus)


The effect of treatment of rats with gentamicin (80 mg/kg/day for 6 days), oral doses of spironolacatone (20 mg/kg/day for 6 days), and the combined treatment (spironolactone + gentamicin) on renal histology and reduced glutathione (GSH) concentration, and some serum constituents indicative of kidney function were studied. The serum concentrations of creatinine and urea were not significantly affected by spironolactone treatment, but were significantly elevated (P

Original languageEnglish
Pages (from-to)20-23
Number of pages4
JournalBasic and Clinical Pharmacology and Toxicology
Issue number1
Publication statusPublished - Jul 2004


ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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