Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats

Badreldin H. Ali, Ali A. Al-Qarawi, Osama M. Mahmoud, Mahmoud Hashad

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of treatment of rats with gentamicin (80 mg/kg/day for 6 days), oral doses of spironolacatone (20 mg/kg/day for 6 days), and the combined treatment (spironolactone + gentamicin) on renal histology and reduced glutathione (GSH) concentration, and some serum constituents indicative of kidney function were studied. The serum concentrations of creatinine and urea were not significantly affected by spironolactone treatment, but were significantly elevated (P

Original languageEnglish
Pages (from-to)20-23
Number of pages4
JournalBasic and Clinical Pharmacology and Toxicology
Volume95
Issue number1
DOIs
Publication statusPublished - Jul 2004

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Spironolactone
Gentamicins
Rats
Histology
Glutathione
Kidney
Urea
Creatinine
Serum
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats. / Ali, Badreldin H.; Al-Qarawi, Ali A.; Mahmoud, Osama M.; Hashad, Mahmoud.

In: Basic and Clinical Pharmacology and Toxicology, Vol. 95, No. 1, 07.2004, p. 20-23.

Research output: Contribution to journalArticle

Ali, Badreldin H. ; Al-Qarawi, Ali A. ; Mahmoud, Osama M. ; Hashad, Mahmoud. / Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats. In: Basic and Clinical Pharmacology and Toxicology. 2004 ; Vol. 95, No. 1. pp. 20-23.
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