TY - JOUR
T1 - Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats
AU - Ali, Badreldin H.
AU - Al-Qarawi, Ali A.
AU - Mahmoud, Osama M.
AU - Hashad, Mahmoud
PY - 2004/7
Y1 - 2004/7
N2 - The effect of treatment of rats with gentamicin (80 mg/kg/day for 6 days), oral doses of spironolacatone (20 mg/kg/day for 6 days), and the combined treatment (spironolactone + gentamicin) on renal histology and reduced glutathione (GSH) concentration, and some serum constituents indicative of kidney function were studied. The serum concentrations of creatinine and urea were not significantly affected by spironolactone treatment, but were significantly elevated (P
AB - The effect of treatment of rats with gentamicin (80 mg/kg/day for 6 days), oral doses of spironolacatone (20 mg/kg/day for 6 days), and the combined treatment (spironolactone + gentamicin) on renal histology and reduced glutathione (GSH) concentration, and some serum constituents indicative of kidney function were studied. The serum concentrations of creatinine and urea were not significantly affected by spironolactone treatment, but were significantly elevated (P
UR - http://www.scopus.com/inward/record.url?scp=3342941546&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3342941546&partnerID=8YFLogxK
U2 - 10.1111/j.1742-7843.2004.pto950105.x
DO - 10.1111/j.1742-7843.2004.pto950105.x
M3 - Article
C2 - 15245572
AN - SCOPUS:3342941546
VL - 95
SP - 20
EP - 23
JO - Basic and Clinical Pharmacology and Toxicology
JF - Basic and Clinical Pharmacology and Toxicology
SN - 1742-7835
IS - 1
ER -