Abstract
The effect of treatment of rats with gentamicin (80 mg/kg/day for 6 days), oral doses of spironolacatone (20 mg/kg/day for 6 days), and the combined treatment (spironolactone + gentamicin) on renal histology and reduced glutathione (GSH) concentration, and some serum constituents indicative of kidney function were studied. The serum concentrations of creatinine and urea were not significantly affected by spironolactone treatment, but were significantly elevated (P
| Original language | English |
|---|---|
| Pages (from-to) | 20-23 |
| Number of pages | 4 |
| Journal | Basic and Clinical Pharmacology and Toxicology |
| Volume | 95 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 2004 |
ASJC Scopus subject areas
- Pharmacology
- Toxicology
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Cite this
Ali, B. H., Al-Qarawi, A. A., Mahmoud, O. M., & Hashad, M. (2004). Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats. Basic and Clinical Pharmacology and Toxicology, 95(1), 20-23. https://doi.org/10.1111/j.1742-7843.2004.pto950105.x