Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats

Badreldin H. Ali; Ali A. Al-Qarawi; Osama M. Mahmoud; Mahmoud Hashad

doi:10.1111/j.1742-7843.2004.pto950105.x

Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats

Badreldin H. Ali, Ali A. Al-Qarawi, Osama M. Mahmoud, Mahmoud Hashad

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

The effect of treatment of rats with gentamicin (80 mg/kg/day for 6 days), oral doses of spironolacatone (20 mg/kg/day for 6 days), and the combined treatment (spironolactone + gentamicin) on renal histology and reduced glutathione (GSH) concentration, and some serum constituents indicative of kidney function were studied. The serum concentrations of creatinine and urea were not significantly affected by spironolactone treatment, but were significantly elevated (P

Original language	English
Pages (from-to)	20-23
Number of pages	4
Journal	Basic and Clinical Pharmacology and Toxicology
Volume	95
Issue number	1
DOIs	https://doi.org/10.1111/j.1742-7843.2004.pto950105.x
Publication status	Published - Jul 2004

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ASJC Scopus subject areas

Pharmacology
Toxicology

Cite this

Ali, B. H., Al-Qarawi, A. A., Mahmoud, O. M., & Hashad, M. (2004). Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats. Basic and Clinical Pharmacology and Toxicology, 95(1), 20-23. https://doi.org/10.1111/j.1742-7843.2004.pto950105.x

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10.1111/j.1742-7843.2004.pto950105.x