Influence of RANTES, SDF-1 and TGF-β levels on the value of interleukin-7 as a predictor of virological response in HIV-1-infected patients receiving double boosted protease inhibitor-based therapy

M. R. Boulassel, G. H.R. Smith, M. D.de B. Edwardes, M. Young, M. Klein, N. Gilmore, J. MacLeod, R. LeBlanc, P. René, J. Allan, R. G. Lalonde, Jean Pierre Routy

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Abstract

Objectives: Interleukin-7 (IL-7), RANTES (regulated on activation, normal T cell expressed and secreted), stromal cell-derived factor-1 (SDF-1) and transforming growth factor-beta (TGF-β) appear to share certain biological properties in vitro and all are involved in HIV-1 disease progression. Our earlier observations indicated that IL-7 levels decrease upon CD4 T-cell recovery and represent a new, independent predictor of virological response. Here, we examine associations among circulating levels of IL-7, RANTES, SDF-1 and TGF-β in hopes of gaining insight into their contribution to the predictive value of IL-7. Methods: Levels of IL-7, RANTES, SDF-1 and TGF-β, and immune and viral parameters were assessed in HIV-1-infected patients. Results: Cross-sectional (n = 148) and longitudinal (n = 36) analyses showed that levels of IL-7, but not RANTES, SDF-1 or TGF-β, were increased in HIV-1-infected adults compared with those of healthy controls. In the cross-sectional study, levels of IL-7 were correlated with RANTES (r = 0.31, P = 0.002) and TGF-β (r= 0.53, P<0.001) but not with SDF-1 (r=0.12, P=0.22), and these associations were more pronounced in patients with CD4 T-cell counts > 200 cells/μL. In contrast to IL-7, levels of RANTES, SDF-1 and TGF-β were not correlated with CD4 T-cell counts. Longitudinal analysis revealed a marked decline in IL-7 levels accompanied by an increase in CD4 T-cell count following antiretroviral therapy (ART), but no changes in RANTES, SDF-1 or TGF-β levels. Multivariate regression analysis showed no influence of baseline RANTES, SDF-1 or TGF-β levels on the value of IL-7 as a predictor of virological response at 48 weeks. Conclusions: Collectively, these results indicate that changes in IL-7 levels did not induce changes in RANTES, SDF-1 or TGF-β. Furthermore, they indicate that RANTES, SDF-1 or TGF-β levels do not explain the predictor value of IL-7 in patients receiving ART.

Original languageEnglish
Pages (from-to)268-277
Number of pages10
JournalHIV Medicine
Volume6
Issue number4
DOIs
Publication statusPublished - Jul 2005

Keywords

  • HIV-1 infection
  • IL-7
  • Predictive value
  • RANTES
  • SDF-1
  • TGF-β

ASJC Scopus subject areas

  • Health Policy
  • Pharmacology (medical)
  • Infectious Diseases

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    Boulassel, M. R., Smith, G. H. R., Edwardes, M. D. D. B., Young, M., Klein, M., Gilmore, N., MacLeod, J., LeBlanc, R., René, P., Allan, J., Lalonde, R. G., & Routy, J. P. (2005). Influence of RANTES, SDF-1 and TGF-β levels on the value of interleukin-7 as a predictor of virological response in HIV-1-infected patients receiving double boosted protease inhibitor-based therapy. HIV Medicine, 6(4), 268-277. https://doi.org/10.1111/j.1468-1293.2005.00306.x